COVID-19 Is Distinct From SARS-CoV-2-Negative Community-Acquired Pneumonia
Background: Corona virus disease (COVID-19) is an infectious respiratory disease that has spread rapidly across the world. Many studies have already evaluated the clinical features of COVID-19, but how it compares with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-negative community-a...
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doaj-e88a6ebf240343a48f2466e107bb8a512020-11-25T02:39:56ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882020-06-011010.3389/fcimb.2020.00322546624COVID-19 Is Distinct From SARS-CoV-2-Negative Community-Acquired PneumoniaYutian Zhou0Shujin Guo1Ye He2Qiunan Zuo3Danju Liu4Meng Xiao5Jinxiu Fan6Xiaohui Li7The Geriatric Respiratory Department of Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaThe Geriatric Respiratory Department of Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaThe Geriatric Respiratory Department of Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaThe Geriatric Respiratory Department of Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaThe Geriatric Respiratory Department of Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaThe Geriatric Respiratory Department of Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaThe Respiratory Department of Wuhan Red Cross Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, ChinaThe Geriatric Respiratory Department of Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, ChinaBackground: Corona virus disease (COVID-19) is an infectious respiratory disease that has spread rapidly across the world. Many studies have already evaluated the clinical features of COVID-19, but how it compares with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-negative community-acquired pneumonia (SN-CAP) is still unclear. Moreover, COVID-19 mortality is correlated with disease severity, but indicators for severity grading have not been specified. We aimed to analyze the clinical characteristics of COVID-19 in comparison with SN-CAP and find indicators for disease severity in COVID-19.Methods: Patients diagnosed with COVID-19 and SN-CAP were enrolled. Clinical, radiological, and laboratory data were analyzed.Results: The numbers of COVID-19 and SN-CAP patients enrolled were 304 and 138, respectively. The age of the patients was not significantly different between the groups. Compared with SN-CAP, COVID-19 patients had more symptoms of fever and dyspnea; and showed significant difference in blood count results. Computed tomography (CT) imaging of COVID-19 patients showed patchy ground-glass opacities that correlated with disease severity, whereas the CT imaging of SN-CAP patients showed patchy high-density shadows. COVID-19 patients were classified into moderate, severe, and critically severe groups. The severe and critically severe groups had elevated levels of white blood cells (WBC), neutrophils, platelets, C-reaction protein (CRP), lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), troponin-I, creatinine, and blood urea nitrogen (BUN). However, they had decreased levels of lymphocytes, lymphocyte ratio, and albumin. Compared with the younger patients, the older COVID-19 individuals had more chronic diseases and significantly elevated levels of WBC, neutrophil, and CRP levels.Conclusion: SN-CAP showed more inflammatory reaction than COVID-19. Old people with chronic diseases are more susceptible to COVID-19 and have a high likelihood of developing severe and critically severe infection. Levels of WBC, lymphocytes, neutrophils, CRP, NLR, PLR, troponin-I, creatinine, and BUN are important indicators for severity grading in COVID-19.https://www.frontiersin.org/article/10.3389/fcimb.2020.00322/fullCOVID-19clinical featuresSARS-CoV-2CAPseverity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yutian Zhou Shujin Guo Ye He Qiunan Zuo Danju Liu Meng Xiao Jinxiu Fan Xiaohui Li |
spellingShingle |
Yutian Zhou Shujin Guo Ye He Qiunan Zuo Danju Liu Meng Xiao Jinxiu Fan Xiaohui Li COVID-19 Is Distinct From SARS-CoV-2-Negative Community-Acquired Pneumonia Frontiers in Cellular and Infection Microbiology COVID-19 clinical features SARS-CoV-2 CAP severity |
author_facet |
Yutian Zhou Shujin Guo Ye He Qiunan Zuo Danju Liu Meng Xiao Jinxiu Fan Xiaohui Li |
author_sort |
Yutian Zhou |
title |
COVID-19 Is Distinct From SARS-CoV-2-Negative Community-Acquired Pneumonia |
title_short |
COVID-19 Is Distinct From SARS-CoV-2-Negative Community-Acquired Pneumonia |
title_full |
COVID-19 Is Distinct From SARS-CoV-2-Negative Community-Acquired Pneumonia |
title_fullStr |
COVID-19 Is Distinct From SARS-CoV-2-Negative Community-Acquired Pneumonia |
title_full_unstemmed |
COVID-19 Is Distinct From SARS-CoV-2-Negative Community-Acquired Pneumonia |
title_sort |
covid-19 is distinct from sars-cov-2-negative community-acquired pneumonia |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2020-06-01 |
description |
Background: Corona virus disease (COVID-19) is an infectious respiratory disease that has spread rapidly across the world. Many studies have already evaluated the clinical features of COVID-19, but how it compares with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-negative community-acquired pneumonia (SN-CAP) is still unclear. Moreover, COVID-19 mortality is correlated with disease severity, but indicators for severity grading have not been specified. We aimed to analyze the clinical characteristics of COVID-19 in comparison with SN-CAP and find indicators for disease severity in COVID-19.Methods: Patients diagnosed with COVID-19 and SN-CAP were enrolled. Clinical, radiological, and laboratory data were analyzed.Results: The numbers of COVID-19 and SN-CAP patients enrolled were 304 and 138, respectively. The age of the patients was not significantly different between the groups. Compared with SN-CAP, COVID-19 patients had more symptoms of fever and dyspnea; and showed significant difference in blood count results. Computed tomography (CT) imaging of COVID-19 patients showed patchy ground-glass opacities that correlated with disease severity, whereas the CT imaging of SN-CAP patients showed patchy high-density shadows. COVID-19 patients were classified into moderate, severe, and critically severe groups. The severe and critically severe groups had elevated levels of white blood cells (WBC), neutrophils, platelets, C-reaction protein (CRP), lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), troponin-I, creatinine, and blood urea nitrogen (BUN). However, they had decreased levels of lymphocytes, lymphocyte ratio, and albumin. Compared with the younger patients, the older COVID-19 individuals had more chronic diseases and significantly elevated levels of WBC, neutrophil, and CRP levels.Conclusion: SN-CAP showed more inflammatory reaction than COVID-19. Old people with chronic diseases are more susceptible to COVID-19 and have a high likelihood of developing severe and critically severe infection. Levels of WBC, lymphocytes, neutrophils, CRP, NLR, PLR, troponin-I, creatinine, and BUN are important indicators for severity grading in COVID-19. |
topic |
COVID-19 clinical features SARS-CoV-2 CAP severity |
url |
https://www.frontiersin.org/article/10.3389/fcimb.2020.00322/full |
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