Synuclein Family Members Prevent Membrane Damage by Counteracting α-Synuclein Aggregation
The 140 amino acid protein α-synuclein (αS) is an intrinsically disordered protein (IDP) with various roles and locations in healthy neurons that plays a key role in Parkinson’s disease (PD). Contact with biomembranes can lead to α-helical conformations, but can also act as s seeding event for aggre...
Main Authors: | Christian Scheibe, Christiaan Karreman, Stefan Schildknecht, Marcel Leist, Karin Hauser |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-07-01
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Series: | Biomolecules |
Subjects: | |
Online Access: | https://www.mdpi.com/2218-273X/11/8/1067 |
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