Differences in clinical severity of respiratory viral infections in hospitalized children
Abstract It is uncertain whether clinical severity of an infection varies by pathogen or by multiple infections. Using hospital-based surveillance in children, we investigate the range of clinical severity for patients singly, multiply, and not infected with a group of commonly circulating viruses i...
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2021-03-01
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doaj-e895ad5f25694278b515ba1b02abda952021-03-11T12:17:53ZengNature Publishing GroupScientific Reports2045-23222021-03-0111111110.1038/s41598-021-84423-2Differences in clinical severity of respiratory viral infections in hospitalized childrenBenjamin M. Althouse0Stefan Flasche1Michiko Toizumi2Hien-Anh Thi Nguyen3Hien Minh Vo4Minh Nhat Le5Masahiro Hashizume6Koya Ariyoshi7Dang Duc Anh8Gail L. Rodgers9Keith P. Klugman10Hao Hu11Lay-Myint Yoshida12Institute for Disease ModelingLondon School of Hygiene and Tropical MedicineInstitute of Tropical Medicine, Nagasaki UniversityNational Institute of Hygiene and EpidemiologyKhanh Hoa General HospitalNational Institute of Hygiene and EpidemiologyInstitute of Tropical Medicine, Nagasaki UniversityInstitute of Tropical Medicine, Nagasaki UniversityNational Institute of Hygiene and EpidemiologyBill & Melinda Gates FoundationBill & Melinda Gates FoundationBill & Melinda Gates FoundationInstitute of Tropical Medicine, Nagasaki UniversityAbstract It is uncertain whether clinical severity of an infection varies by pathogen or by multiple infections. Using hospital-based surveillance in children, we investigate the range of clinical severity for patients singly, multiply, and not infected with a group of commonly circulating viruses in Nha Trang, Vietnam. RT-PCR was performed to detect 13 respiratory viruses in nasopharyngeal samples from enrolled patients. We apply a novel clinical severity score and examine associations with the odds of being severe and differences in raw severity scores. We find no difference in severity between 0-, 1-, and 2-concurrent infections and little differences in severity between specific viruses. We find RSV and HMPV infections to be associated with 2- and 1.5-fold increase in odds of being severe, respectively, and that infection with ADV is consistently associated with lower risk of severity. Clinically, based on the results here, if RSV or HMPV virus is suspected, PCR testing for confirmatory diagnosis and for detection of multiple coinfecting viruses would be fruitful to assess whether a patient’s disease course is going to be severe.https://doi.org/10.1038/s41598-021-84423-2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Benjamin M. Althouse Stefan Flasche Michiko Toizumi Hien-Anh Thi Nguyen Hien Minh Vo Minh Nhat Le Masahiro Hashizume Koya Ariyoshi Dang Duc Anh Gail L. Rodgers Keith P. Klugman Hao Hu Lay-Myint Yoshida |
spellingShingle |
Benjamin M. Althouse Stefan Flasche Michiko Toizumi Hien-Anh Thi Nguyen Hien Minh Vo Minh Nhat Le Masahiro Hashizume Koya Ariyoshi Dang Duc Anh Gail L. Rodgers Keith P. Klugman Hao Hu Lay-Myint Yoshida Differences in clinical severity of respiratory viral infections in hospitalized children Scientific Reports |
author_facet |
Benjamin M. Althouse Stefan Flasche Michiko Toizumi Hien-Anh Thi Nguyen Hien Minh Vo Minh Nhat Le Masahiro Hashizume Koya Ariyoshi Dang Duc Anh Gail L. Rodgers Keith P. Klugman Hao Hu Lay-Myint Yoshida |
author_sort |
Benjamin M. Althouse |
title |
Differences in clinical severity of respiratory viral infections in hospitalized children |
title_short |
Differences in clinical severity of respiratory viral infections in hospitalized children |
title_full |
Differences in clinical severity of respiratory viral infections in hospitalized children |
title_fullStr |
Differences in clinical severity of respiratory viral infections in hospitalized children |
title_full_unstemmed |
Differences in clinical severity of respiratory viral infections in hospitalized children |
title_sort |
differences in clinical severity of respiratory viral infections in hospitalized children |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-03-01 |
description |
Abstract It is uncertain whether clinical severity of an infection varies by pathogen or by multiple infections. Using hospital-based surveillance in children, we investigate the range of clinical severity for patients singly, multiply, and not infected with a group of commonly circulating viruses in Nha Trang, Vietnam. RT-PCR was performed to detect 13 respiratory viruses in nasopharyngeal samples from enrolled patients. We apply a novel clinical severity score and examine associations with the odds of being severe and differences in raw severity scores. We find no difference in severity between 0-, 1-, and 2-concurrent infections and little differences in severity between specific viruses. We find RSV and HMPV infections to be associated with 2- and 1.5-fold increase in odds of being severe, respectively, and that infection with ADV is consistently associated with lower risk of severity. Clinically, based on the results here, if RSV or HMPV virus is suspected, PCR testing for confirmatory diagnosis and for detection of multiple coinfecting viruses would be fruitful to assess whether a patient’s disease course is going to be severe. |
url |
https://doi.org/10.1038/s41598-021-84423-2 |
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