Risk factors and obstetric complications of large for gestational age births with adjustments for community effects: results from a new cohort study
<p>Abstract</p> <p>Background</p> <p>High birth weight has serious adverse impacts on chronic health conditions and development in children. This study identifies the social determinants and obstetric complications of high birth weight adjusted for gestational age and b...
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doaj-e895d8902097444db0c01c7dbb4516f62020-11-25T01:01:29ZengBMCBMC Public Health1471-24582010-08-0110146010.1186/1471-2458-10-460Risk factors and obstetric complications of large for gestational age births with adjustments for community effects: results from a new cohort studyCameron Cate MSpinks Anneliese BOlog AdrianaNg Shu-KaySearle JudyMcClure Rod J<p>Abstract</p> <p>Background</p> <p>High birth weight has serious adverse impacts on chronic health conditions and development in children. This study identifies the social determinants and obstetric complications of high birth weight adjusted for gestational age and baby gender.</p> <p>Methods</p> <p>Pregnant women were recruited from three maternity hospitals in South-East Queensland in Australia during antenatal clinic visits. A questionnaire was completed by each participant to elicit information on eco-epidemiological exposures. Perinatal information was extracted from hospital birth records. A hierarchical mixture regression model was used in the analysis to account for the heterogeneity of birth weights and identify risk factors and obstetric complications of births that were large for gestational age. A generalized linear mixed model was used to adjust for (random) "community" effects.</p> <p>Results</p> <p>Pre-pregnancy obesity (adjusted OR = 2.73, 95% CI = 1.49-5.01), previous pregnancy (adjusted OR = 2.03, 95% CI = 1.08-3.81), and married mothers (adjusted OR = 1.85, 95% CI = 1.00-3.42) were significantly associated with large for gestational age babies. Subsequent complications included the increased need for delivery by caesarean sections or instrumental procedures (adjusted OR = 1.98, 95% CI = 1.10-3.55), resuscitation (adjusted OR = 2.52, 95% CI = 1.33-4.79), and transfer to intensive/special care nursery (adjusted OR = 3.76, 95% CI = 1.89-7.49). Communities associated with a higher proportion of large for gestational age births were identified.</p> <p>Conclusions</p> <p>Pre pregnancy obesity is the principal modifiable risk factor for large for gestational age births. Large for gestational age is an important risk factor for the subsequent obstetric complications. The findings improve the evidence-base on which to base preventive interventions to reduce the impact of high birth weight on maternal and child health.</p> http://www.biomedcentral.com/1471-2458/10/460 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cameron Cate M Spinks Anneliese B Olog Adriana Ng Shu-Kay Searle Judy McClure Rod J |
spellingShingle |
Cameron Cate M Spinks Anneliese B Olog Adriana Ng Shu-Kay Searle Judy McClure Rod J Risk factors and obstetric complications of large for gestational age births with adjustments for community effects: results from a new cohort study BMC Public Health |
author_facet |
Cameron Cate M Spinks Anneliese B Olog Adriana Ng Shu-Kay Searle Judy McClure Rod J |
author_sort |
Cameron Cate M |
title |
Risk factors and obstetric complications of large for gestational age births with adjustments for community effects: results from a new cohort study |
title_short |
Risk factors and obstetric complications of large for gestational age births with adjustments for community effects: results from a new cohort study |
title_full |
Risk factors and obstetric complications of large for gestational age births with adjustments for community effects: results from a new cohort study |
title_fullStr |
Risk factors and obstetric complications of large for gestational age births with adjustments for community effects: results from a new cohort study |
title_full_unstemmed |
Risk factors and obstetric complications of large for gestational age births with adjustments for community effects: results from a new cohort study |
title_sort |
risk factors and obstetric complications of large for gestational age births with adjustments for community effects: results from a new cohort study |
publisher |
BMC |
series |
BMC Public Health |
issn |
1471-2458 |
publishDate |
2010-08-01 |
description |
<p>Abstract</p> <p>Background</p> <p>High birth weight has serious adverse impacts on chronic health conditions and development in children. This study identifies the social determinants and obstetric complications of high birth weight adjusted for gestational age and baby gender.</p> <p>Methods</p> <p>Pregnant women were recruited from three maternity hospitals in South-East Queensland in Australia during antenatal clinic visits. A questionnaire was completed by each participant to elicit information on eco-epidemiological exposures. Perinatal information was extracted from hospital birth records. A hierarchical mixture regression model was used in the analysis to account for the heterogeneity of birth weights and identify risk factors and obstetric complications of births that were large for gestational age. A generalized linear mixed model was used to adjust for (random) "community" effects.</p> <p>Results</p> <p>Pre-pregnancy obesity (adjusted OR = 2.73, 95% CI = 1.49-5.01), previous pregnancy (adjusted OR = 2.03, 95% CI = 1.08-3.81), and married mothers (adjusted OR = 1.85, 95% CI = 1.00-3.42) were significantly associated with large for gestational age babies. Subsequent complications included the increased need for delivery by caesarean sections or instrumental procedures (adjusted OR = 1.98, 95% CI = 1.10-3.55), resuscitation (adjusted OR = 2.52, 95% CI = 1.33-4.79), and transfer to intensive/special care nursery (adjusted OR = 3.76, 95% CI = 1.89-7.49). Communities associated with a higher proportion of large for gestational age births were identified.</p> <p>Conclusions</p> <p>Pre pregnancy obesity is the principal modifiable risk factor for large for gestational age births. Large for gestational age is an important risk factor for the subsequent obstetric complications. The findings improve the evidence-base on which to base preventive interventions to reduce the impact of high birth weight on maternal and child health.</p> |
url |
http://www.biomedcentral.com/1471-2458/10/460 |
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