Anti-diarrheal and hypoglycemic activities of methanol extract of Calamus rotang L. seed in rat
Background and objectives: Calamus rotang is used in traditional medicine. Regarding the previous phytochemical screening of methanol extract of Calamus rotang L. fruits (MCR), this study was performed to find out the antidiarrheal and hypoglycemic effects of the experimented extract in rodents. Met...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Iranian Society of Pharmacognosy
2016-04-01
|
Series: | Research Journal of Pharmacognosy |
Subjects: | |
Online Access: | http://www.rjpharmacognosy.ir/article_13774_54bb3b6db1c822c6ed053e058145a02c.pdf |
id |
doaj-e8960458f44d4acc966d1835223fcd1e |
---|---|
record_format |
Article |
spelling |
doaj-e8960458f44d4acc966d1835223fcd1e2020-11-24T20:52:59ZengIranian Society of PharmacognosyResearch Journal of Pharmacognosy2345-44582345-59772016-04-0132334013774Anti-diarrheal and hypoglycemic activities of methanol extract of Calamus rotang L. seed in ratF.A. Ripa0P.R. Dash1A.K. Podder2Department of Pharmacy, BRAC University, Mohakhali, Dhaka, BangladeshDepartment of Pharmacy, BRAC University, Mohakhali, Dhaka, BangladeshDepartment of Pharmacy, BRAC University, Mohakhali, Dhaka, Bangladesh.Background and objectives: Calamus rotang is used in traditional medicine. Regarding the previous phytochemical screening of methanol extract of Calamus rotang L. fruits (MCR), this study was performed to find out the antidiarrheal and hypoglycemic effects of the experimented extract in rodents. Methods: Castor oil induced diarrheal test was followed for screening anti-diarrheal effect of MCR. In order to explore the hypoglycemic effect, normoglycemic study, oral glucose tolerance test (OGTT) and study on alloxan-induced diabetic rats were carried out. In each experiment, 250 and 500 mg/kg body weight doses of MCR were used. Results: The plant extract showed pronounced, significant (p < 0.01) antidiarrheal activity on both doses in a dose-dependent manner. At higher dose, MCR showed almost similar antidiarrheal effect as standard loperamide. In case of normoglycemic test, a single dose of MCR caused a significant (phttp://www.rjpharmacognosy.ir/article_13774_54bb3b6db1c822c6ed053e058145a02c.pdfalloxaneantidiarrheal effectCalamus rotangdiabeteshypoglycemic effect |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
F.A. Ripa P.R. Dash A.K. Podder |
spellingShingle |
F.A. Ripa P.R. Dash A.K. Podder Anti-diarrheal and hypoglycemic activities of methanol extract of Calamus rotang L. seed in rat Research Journal of Pharmacognosy alloxane antidiarrheal effect Calamus rotang diabetes hypoglycemic effect |
author_facet |
F.A. Ripa P.R. Dash A.K. Podder |
author_sort |
F.A. Ripa |
title |
Anti-diarrheal and hypoglycemic activities of methanol extract of Calamus rotang L. seed in rat |
title_short |
Anti-diarrheal and hypoglycemic activities of methanol extract of Calamus rotang L. seed in rat |
title_full |
Anti-diarrheal and hypoglycemic activities of methanol extract of Calamus rotang L. seed in rat |
title_fullStr |
Anti-diarrheal and hypoglycemic activities of methanol extract of Calamus rotang L. seed in rat |
title_full_unstemmed |
Anti-diarrheal and hypoglycemic activities of methanol extract of Calamus rotang L. seed in rat |
title_sort |
anti-diarrheal and hypoglycemic activities of methanol extract of calamus rotang l. seed in rat |
publisher |
Iranian Society of Pharmacognosy |
series |
Research Journal of Pharmacognosy |
issn |
2345-4458 2345-5977 |
publishDate |
2016-04-01 |
description |
Background and objectives: Calamus rotang is used in traditional medicine. Regarding the previous phytochemical screening of methanol extract of Calamus rotang L. fruits (MCR), this study was performed to find out the antidiarrheal and hypoglycemic effects of the experimented extract in rodents. Methods: Castor oil induced diarrheal test was followed for screening anti-diarrheal effect of MCR. In order to explore the hypoglycemic effect, normoglycemic study, oral glucose tolerance test (OGTT) and study on alloxan-induced diabetic rats were carried out. In each experiment, 250 and 500 mg/kg body weight doses of MCR were used. Results: The plant extract showed pronounced, significant (p < 0.01) antidiarrheal activity on both doses in a dose-dependent manner. At higher dose, MCR showed almost similar antidiarrheal effect as standard loperamide. In case of normoglycemic test, a single dose of MCR caused a significant (p |
topic |
alloxane antidiarrheal effect Calamus rotang diabetes hypoglycemic effect |
url |
http://www.rjpharmacognosy.ir/article_13774_54bb3b6db1c822c6ed053e058145a02c.pdf |
work_keys_str_mv |
AT faripa antidiarrhealandhypoglycemicactivitiesofmethanolextractofcalamusrotanglseedinrat AT prdash antidiarrhealandhypoglycemicactivitiesofmethanolextractofcalamusrotanglseedinrat AT akpodder antidiarrhealandhypoglycemicactivitiesofmethanolextractofcalamusrotanglseedinrat |
_version_ |
1716798454526640128 |