Protein kinase C is a calcium sensor for presynaptic short-term plasticity
In presynaptic boutons, calcium (Ca2+) triggers both neurotransmitter release and short-term synaptic plasticity. Whereas synaptotagmins are known to mediate vesicle fusion through binding of high local Ca2+ to their C2 domains, the proteins that sense smaller global Ca2+ increases to produce short-...
Main Authors: | Diasynou Fioravante, YunXiang Chu, Arthur PH de Jong, Michael Leitges, Pascal S Kaeser, Wade G Regehr |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2014-08-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/03011 |
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