Assessment of violations of the proteomic profile in blood plasma in children being under inhalation exposure to fine dust containing vanadium

• Main Authors: N.V. Zaitseva, М.А. Zemlyanova
• Format: Article
• Language: English
• Published: FBSI “Federal Scientific Center for Medical and Preventive Health Risk Management Technologies” 2016-03-01
• Series: Analiz Riska Zdorovʹû
• Subjects: proteomic profile; blood plasma; vanadium; molecular markers
• Online Access: http://journal.fcrisk.ru/eng/2016/1/3
• ISSN: 2308-1155; 2308-1163

The results of research and evaluation of the protein profile in blood plasma in children, that have been exposed to long-term effect of fine dust containing vanadium in the zone of influence of metallurgical production sources, are demonstrated. It was established that under conditions of poor air quality in the residential area due to vanadium pentoxide dust content at the level up to 1.2 mean daily MAC (34 RfC chr ), by the suspended solids – up to 0.6 mean daily MAC (1.2 RfC chr ), there is vanadium concentration in blood of the exposed 4–7 aged children, that exceeds up to 6 times the reference level. The technology of the proteomic analysis showed that children with high content of vanadium in blood have changes in proteomic profile in blood plasma in the type of increase of the relative volume of acid glycoprotein alpha-1; reduction of clusterin, apolipoprotein A-IV, alpha-2-HS-glycoprotein, that are associated with vanadium concentration in blood. In the absence of timely primary and secondary prevention and the preservation of vanadium sustained exposure the revealed cell-molecular abnormalities allow us to predict further development of functional disturbances on tissue and organ levels as the early development of osteoporosis and osteoarticular pathology, atherosclerotic vascular changes, autoimmune allergic processes on the background of disorders of immune regulation, oncology diseases.