Defining therapeutic targets for renal fibrosis: Exploiting the biology of pathogenesis

Defining therapeutic targets for renal fibrosis: Exploiting the biology of pathogenesis

Renal fibrosis is a failed wound-healing process of the kidney tissue after chronic, sustained injury, which is a common pathway and pathological marker of virtually every type of chronic kidney disease (CKD), regardless of cause. However, there is a lack of effective treatment specifically targetin...

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Main Authors: Hao Yan, Jiangxin Xu, Zhifei Xu, Bo Yang, Peihua Luo, Qiaojun He
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Renal fibrosis
Chronic kidney disease
Renal tubular epithelial cells
Inflammation
Therapeutic strategy
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221008994
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spelling doaj-e8c12482408443cfb2693f55beb8bb162021-10-11T04:14:37ZengElsevierBiomedicine & Pharmacotherapy0753-33222021-11-01143112115Defining therapeutic targets for renal fibrosis: Exploiting the biology of pathogenesisHao Yan0Jiangxin Xu1Zhifei Xu2Bo Yang3Peihua Luo4Qiaojun He5Center for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, ChinaCenter for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, ChinaCenter for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, ChinaInstitute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, ChinaCenter for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Correspondence to: Zhejiang University, Zijingang Campus, #866 Yuhangtang Road, Hangzhou, Zhejiang, China.Center for Drug Safety Evaluation and Research of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Correspondence to: Zhejiang University, Zijingang Campus, #866 Yuhangtang Road, Hangzhou, Zhejiang, China.Renal fibrosis is a failed wound-healing process of the kidney tissue after chronic, sustained injury, which is a common pathway and pathological marker of virtually every type of chronic kidney disease (CKD), regardless of cause. However, there is a lack of effective treatment specifically targeting against renal fibrosis per se to date. The main pathological feature of renal fibrosis is the massive activation and proliferation of renal fibroblasts and the excessive synthesis and secretion of extracellular matrix (ECM) deposited in the renal interstitium, leading to structural damage, impairment of renal function, and eventually end-stage renal disease. In this review, we summarize recent advancements regarding the participation and interaction of many types of kidney residents and infiltrated cells during renal fibrosis, attempt to comprehensively discuss the mechanism of renal fibrosis from the cellular level and conclude by highlighting novel therapeutic targets and approaches for development of new treatments for patients with renal fibrosis.http://www.sciencedirect.com/science/article/pii/S0753332221008994Renal fibrosisChronic kidney diseaseRenal tubular epithelial cellsInflammationTherapeutic strategy
collection DOAJ
language English
format Article
sources DOAJ
author Hao Yan
Jiangxin Xu
Zhifei Xu
Bo Yang
Peihua Luo
Qiaojun He
spellingShingle Hao Yan
Jiangxin Xu
Zhifei Xu
Bo Yang
Peihua Luo
Qiaojun He
Defining therapeutic targets for renal fibrosis: Exploiting the biology of pathogenesis
Biomedicine & Pharmacotherapy
Renal fibrosis
Chronic kidney disease
Renal tubular epithelial cells
Inflammation
Therapeutic strategy
author_facet Hao Yan
Jiangxin Xu
Zhifei Xu
Bo Yang
Peihua Luo
Qiaojun He
author_sort Hao Yan
title Defining therapeutic targets for renal fibrosis: Exploiting the biology of pathogenesis
title_short Defining therapeutic targets for renal fibrosis: Exploiting the biology of pathogenesis
title_full Defining therapeutic targets for renal fibrosis: Exploiting the biology of pathogenesis
title_fullStr Defining therapeutic targets for renal fibrosis: Exploiting the biology of pathogenesis
title_full_unstemmed Defining therapeutic targets for renal fibrosis: Exploiting the biology of pathogenesis
title_sort defining therapeutic targets for renal fibrosis: exploiting the biology of pathogenesis
publisher Elsevier
series Biomedicine & Pharmacotherapy
issn 0753-3322
publishDate 2021-11-01
description Renal fibrosis is a failed wound-healing process of the kidney tissue after chronic, sustained injury, which is a common pathway and pathological marker of virtually every type of chronic kidney disease (CKD), regardless of cause. However, there is a lack of effective treatment specifically targeting against renal fibrosis per se to date. The main pathological feature of renal fibrosis is the massive activation and proliferation of renal fibroblasts and the excessive synthesis and secretion of extracellular matrix (ECM) deposited in the renal interstitium, leading to structural damage, impairment of renal function, and eventually end-stage renal disease. In this review, we summarize recent advancements regarding the participation and interaction of many types of kidney residents and infiltrated cells during renal fibrosis, attempt to comprehensively discuss the mechanism of renal fibrosis from the cellular level and conclude by highlighting novel therapeutic targets and approaches for development of new treatments for patients with renal fibrosis.
topic Renal fibrosis
Chronic kidney disease
Renal tubular epithelial cells
Inflammation
Therapeutic strategy
url http://www.sciencedirect.com/science/article/pii/S0753332221008994
work_keys_str_mv AT haoyan definingtherapeutictargetsforrenalfibrosisexploitingthebiologyofpathogenesis
AT jiangxinxu definingtherapeutictargetsforrenalfibrosisexploitingthebiologyofpathogenesis
AT zhifeixu definingtherapeutictargetsforrenalfibrosisexploitingthebiologyofpathogenesis
AT boyang definingtherapeutictargetsforrenalfibrosisexploitingthebiologyofpathogenesis
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AT qiaojunhe definingtherapeutictargetsforrenalfibrosisexploitingthebiologyofpathogenesis
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