Silver Nanoparticles Supported on Chitosan as a Green and Robust Heterogeneous Catalyst for Direct Synthesis of Nitrogen Heterocyclic Compounds under Green Conditions

• Main Authors: Seyedeh Fazileh Fazileh Hamzavi, Shahla Jamili, Morteza Yousefzadi, Ali Mashinchian Moradi, Narges Amrollahi Biuki
• Format: Article
• Language: English
• Published: Diponegoro University 2019-04-01
• Series: Bulletin of Chemical Reaction Engineering & Catalysis
• Subjects: chitosan; silver nanoparticles; heterogeneous catalyst; heterocyclic compounds; green chemistry
• Online Access: https://ejournal2.undip.ac.id/index.php/bcrec/article/view/2105
• ISSN: 1978-2993

The catalytic efficiency of silver nanoparticles supported on chitosan as a green, robust, and efficient nanocatalyst for the direct synthesis of biologically active compounds, such as: imidazole derivatives as well as pyrazine scaffolds through multi-component reactions strategy, have been demonstrated. In this work, imidazole derivatives were achieved via pseudo four-component reactions by utilization of benzaldehydes, benzils, anilines, and ammonium acetate under solvent-free conditions. Moreover, pyrazine scaffolds were synthesized through a three-component reaction of phenylenediamine derivatives, isocyanides and various ketones in water. The main advantages of this protocol are the  reusability of the catalyst, operational simplicity, mild reaction conditions, and high-yielding. Copyright © 2019 BCREC Group. All rights reserved