In vivo Diagnosis of Primary Cutaneous Amyloidosis —The Role of Reflectance Confocal Microscopy
Primary cutaneous amyloidosis (PCA) is a form of localized amyloidosis. It is characterized by the deposition of a fibrillar material in the superficial dermis, without affecting other systems or organs. The diagnosis can be made clinically, but usually a skin biopsy is performed in order to exclude...
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doaj-e8e3cdb9be0041ea84af3e9c7d076efc2020-11-25T01:49:48ZengMDPI AGDiagnostics2075-44182019-06-01936610.3390/diagnostics9030066diagnostics9030066In vivo Diagnosis of Primary Cutaneous Amyloidosis —The Role of Reflectance Confocal MicroscopyAna-Maria Ionescu0Mihaela-Adriana Ilie1Virginia Chitu2Andrei Razvan3Daniela Lixandru4Cristiana Tanase5Daniel Boda6Constantin Caruntu7Sabina Zurac8First Department of Dermatology, Colentina Clinical Hospital, 020125 Bucharest, RomaniaDermatology Research Laboratory, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaFirst Department of Dermatology, Colentina Clinical Hospital, 020125 Bucharest, RomaniaDepartment of Pathology, Colentina Clinical Hospital, 020125 Bucharest, RomaniaDepartment of Biochemistry, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Biochemistry-Proteomics, “Victor Babes” National Institute of Pathology, 050096 Bucharest, RomaniaDermatology Research Laboratory, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaDepartment of Dermatology, “Prof. N. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Diseases, 011233 Bucharest, RomaniaDepartment of Dermatology, “Carol Davila” University of Medicine and Pharmacy, 050474 Bucharest, RomaniaPrimary cutaneous amyloidosis (PCA) is a form of localized amyloidosis. It is characterized by the deposition of a fibrillar material in the superficial dermis, without affecting other systems or organs. The diagnosis can be made clinically, but usually a skin biopsy is performed in order to exclude other skin diseases with similar appearance. Reflectance confocal microscopy (RCM) is a novel imaging tool that enables in vivo characterization of various skin changes with a high, quasi-microscopic resolution. This technique might have an important role in the differential diagnosis of cutaneous amyloidosis, by the in vivo assessment of epidermal changes and dermal amyloid deposition. Moreover, it is completely non-invasive and can be safely repeated on the same skin area. However, to date, there is only one published paper presenting the confocal features of primary cutaneous amyloidosis. Hereby, we describe the in vivo RCM features of PCA lesions from a patient with diabetes and correlate them with histologic findings. This strengthens the clinical usefulness of in vivo RCM examination for the non-invasive diagnosis of cutaneous amyloidosis, especially in patients that might associate diseases with impaired wound healing.https://www.mdpi.com/2075-4418/9/3/66cutaneous amyloidosisin vivonon-invasivereflectance confocal microscopy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ana-Maria Ionescu Mihaela-Adriana Ilie Virginia Chitu Andrei Razvan Daniela Lixandru Cristiana Tanase Daniel Boda Constantin Caruntu Sabina Zurac |
spellingShingle |
Ana-Maria Ionescu Mihaela-Adriana Ilie Virginia Chitu Andrei Razvan Daniela Lixandru Cristiana Tanase Daniel Boda Constantin Caruntu Sabina Zurac In vivo Diagnosis of Primary Cutaneous Amyloidosis —The Role of Reflectance Confocal Microscopy Diagnostics cutaneous amyloidosis in vivo non-invasive reflectance confocal microscopy |
author_facet |
Ana-Maria Ionescu Mihaela-Adriana Ilie Virginia Chitu Andrei Razvan Daniela Lixandru Cristiana Tanase Daniel Boda Constantin Caruntu Sabina Zurac |
author_sort |
Ana-Maria Ionescu |
title |
In vivo Diagnosis of Primary Cutaneous Amyloidosis —The Role of Reflectance Confocal Microscopy |
title_short |
In vivo Diagnosis of Primary Cutaneous Amyloidosis —The Role of Reflectance Confocal Microscopy |
title_full |
In vivo Diagnosis of Primary Cutaneous Amyloidosis —The Role of Reflectance Confocal Microscopy |
title_fullStr |
In vivo Diagnosis of Primary Cutaneous Amyloidosis —The Role of Reflectance Confocal Microscopy |
title_full_unstemmed |
In vivo Diagnosis of Primary Cutaneous Amyloidosis —The Role of Reflectance Confocal Microscopy |
title_sort |
in vivo diagnosis of primary cutaneous amyloidosis —the role of reflectance confocal microscopy |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2019-06-01 |
description |
Primary cutaneous amyloidosis (PCA) is a form of localized amyloidosis. It is characterized by the deposition of a fibrillar material in the superficial dermis, without affecting other systems or organs. The diagnosis can be made clinically, but usually a skin biopsy is performed in order to exclude other skin diseases with similar appearance. Reflectance confocal microscopy (RCM) is a novel imaging tool that enables in vivo characterization of various skin changes with a high, quasi-microscopic resolution. This technique might have an important role in the differential diagnosis of cutaneous amyloidosis, by the in vivo assessment of epidermal changes and dermal amyloid deposition. Moreover, it is completely non-invasive and can be safely repeated on the same skin area. However, to date, there is only one published paper presenting the confocal features of primary cutaneous amyloidosis. Hereby, we describe the in vivo RCM features of PCA lesions from a patient with diabetes and correlate them with histologic findings. This strengthens the clinical usefulness of in vivo RCM examination for the non-invasive diagnosis of cutaneous amyloidosis, especially in patients that might associate diseases with impaired wound healing. |
topic |
cutaneous amyloidosis in vivo non-invasive reflectance confocal microscopy |
url |
https://www.mdpi.com/2075-4418/9/3/66 |
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