Prospects of IL-2 in Cancer Immunotherapy

Prospects of IL-2 in Cancer Immunotherapy

IL-2 is a powerful immune growth factor and it plays important role in sustaining T cell response. The potential of IL-2 in expanding T cells without loss of functionality has led to its early use in cancer immunotherapy. IL-2 has been reported to induce complete and durable regressions in cancer pa...

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Main Authors: Hani Choudhry, Nawal Helmi, Wesam H. Abdulaal, Mustafa Zeyadi, Mazin A. Zamzami, Wei Wu, Maged Mostafa Mahmoud, Mohiuddin Khan Warsi, Mahmood Rasool, Mohammad S. Jamal
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2018/9056173
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spelling doaj-e8e6f6a349c44ef097ddc1fadebb80ee2020-11-25T02:29:37ZengHindawi LimitedBioMed Research International2314-61332314-61412018-01-01201810.1155/2018/90561739056173Prospects of IL-2 in Cancer ImmunotherapyHani Choudhry0Nawal Helmi1Wesam H. Abdulaal2Mustafa Zeyadi3Mazin A. Zamzami4Wei Wu5Maged Mostafa Mahmoud6Mohiuddin Khan Warsi7Mahmood Rasool8Mohammad S. Jamal9Department of Biochemistry, Cancer Metabolism and Epigenetic Unit, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Saudi ArabiaDepartment of Biochemistry, Cancer Metabolism and Epigenetic Unit, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Saudi ArabiaDepartment of Biochemistry, Cancer Metabolism and Epigenetic Unit, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Saudi ArabiaDepartment of Biochemistry, Cancer Metabolism and Epigenetic Unit, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Saudi ArabiaDepartment of Biochemistry, Cancer Metabolism and Epigenetic Unit, Faculty of Science, Cancer and Mutagenesis Unit, King Fahd Center for Medical Research, King Abdulaziz University, Jeddah, Saudi ArabiaDepartment of Medicine, University of California, San Francisco, CA 94143, USAKing Fahd Medical Research, King Abdulaziz University, Jeddah, Saudi ArabiaDepartment of Biochemistry, University of Jeddah, Jeddah, Saudi ArabiaCenter of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, Saudi ArabiaKing Fahd Medical Research, King Abdulaziz University, Jeddah, Saudi ArabiaIL-2 is a powerful immune growth factor and it plays important role in sustaining T cell response. The potential of IL-2 in expanding T cells without loss of functionality has led to its early use in cancer immunotherapy. IL-2 has been reported to induce complete and durable regressions in cancer patients but immune related adverse effects have been reported (irAE). The present review discusses the prospects of IL-2 in immunotherapy for cancer.http://dx.doi.org/10.1155/2018/9056173
collection DOAJ
language English
format Article
sources DOAJ
author Hani Choudhry
Nawal Helmi
Wesam H. Abdulaal
Mustafa Zeyadi
Mazin A. Zamzami
Wei Wu
Maged Mostafa Mahmoud
Mohiuddin Khan Warsi
Mahmood Rasool
Mohammad S. Jamal
spellingShingle Hani Choudhry
Nawal Helmi
Wesam H. Abdulaal
Mustafa Zeyadi
Mazin A. Zamzami
Wei Wu
Maged Mostafa Mahmoud
Mohiuddin Khan Warsi
Mahmood Rasool
Mohammad S. Jamal
Prospects of IL-2 in Cancer Immunotherapy
BioMed Research International
author_facet Hani Choudhry
Nawal Helmi
Wesam H. Abdulaal
Mustafa Zeyadi
Mazin A. Zamzami
Wei Wu
Maged Mostafa Mahmoud
Mohiuddin Khan Warsi
Mahmood Rasool
Mohammad S. Jamal
author_sort Hani Choudhry
title Prospects of IL-2 in Cancer Immunotherapy
title_short Prospects of IL-2 in Cancer Immunotherapy
title_full Prospects of IL-2 in Cancer Immunotherapy
title_fullStr Prospects of IL-2 in Cancer Immunotherapy
title_full_unstemmed Prospects of IL-2 in Cancer Immunotherapy
title_sort prospects of il-2 in cancer immunotherapy
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2018-01-01
description IL-2 is a powerful immune growth factor and it plays important role in sustaining T cell response. The potential of IL-2 in expanding T cells without loss of functionality has led to its early use in cancer immunotherapy. IL-2 has been reported to induce complete and durable regressions in cancer patients but immune related adverse effects have been reported (irAE). The present review discusses the prospects of IL-2 in immunotherapy for cancer.
url http://dx.doi.org/10.1155/2018/9056173
work_keys_str_mv AT hanichoudhry prospectsofil2incancerimmunotherapy
AT nawalhelmi prospectsofil2incancerimmunotherapy
AT wesamhabdulaal prospectsofil2incancerimmunotherapy
AT mustafazeyadi prospectsofil2incancerimmunotherapy
AT mazinazamzami prospectsofil2incancerimmunotherapy
AT weiwu prospectsofil2incancerimmunotherapy
AT magedmostafamahmoud prospectsofil2incancerimmunotherapy
AT mohiuddinkhanwarsi prospectsofil2incancerimmunotherapy
AT mahmoodrasool prospectsofil2incancerimmunotherapy
AT mohammadsjamal prospectsofil2incancerimmunotherapy
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