Tdp1 Inhibition as a Promising Approach to New Anticancer Drugs

Tdp1 Inhibition as a Promising Approach to New Anticancer Drugs

The cytotoxic effects of chemotherapy and radiation that are clinically used to treat malignancies are directly related to their propensity to generate DNA damage. [...]

Bibliographic Details
Main Authors:	Konstantin Volcho, Alexandra Zakharenko, Olga Luzina, Tatyana Khomenko, Evgeniy Suslov, Oksana Salomatina, Olga Zakharova, Nikolai Li-Zhulanov, Jóhannes Reynisson, Olga Lavrik, Nariman Salakhutdinov
Format:	Article
Language:	English
Published:	MDPI AG 2019-08-01
Series:	Proceedings
Subjects:	anticancer agent Tdp1 inhibitor DNA repair enzyme synthesis usnic acid pentathiepine adamantane molecular modeling terpene coumarin
Online Access:	https://www.mdpi.com/2504-3900/22/1/35

Similar Items

New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition
by: Nadezhda S. Dyrkheeva, et al.
Published: (2021-07-01)

Design, Synthesis, and Molecular Docking Study of New Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors Combining Resin Acids and Adamantane Moieties
by: Kseniya Kovaleva, et al.
Published: (2021-05-01)

New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors
by: Aleksander S. Filimonov, et al.
Published: (2019-10-01)

Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors
by: Elizaveta D. Gladkova, et al.
Published: (2021-03-01)

Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy
by: Tatyana M. Khomenko, et al.
Published: (2019-12-01)

The First Berberine-based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme
by: Elizaveta D. Gladkova, et al.
Published: (2020-09-01)

Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1
by: Irina V. Il’ina, et al.
Published: (2020-07-01)

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors
by: Oksana V. Salomatina, et al.
Published: (2018-03-01)

A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold
by: Nikolai S. Li-Zhulanov, et al.
Published: (2018-09-01)

TDP-43 and Phosphorylated TDP-43 Levels in Paired Plasma and CSF Samples in Amyotrophic Lateral Sclerosis
by: Yuting Ren, et al.
Published: (2021-06-01)

Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments
by: Aldar A. Munkuev, et al.
Published: (2021-05-01)

Comprehensive Evaluation of Biological Effects of Pentathiepins on Various Human Cancer Cell Lines and Insights into Their Mode of Action
by: Lisa Wolff, et al.
Published: (2021-07-01)

The study of the thermal decomposition of Tetracyclo[3.3.1.1[sup 3,7].0[sup 1,3]]decane in octane and cumene at 1950
by: McIntyre, Brian William
Published: (2010)

Application of He-Ne laser combined with TDP irradiation in the treatment of herpes zoster ophthalmicus
by: Qi-Hua Xu, et al.
Published: (2017-07-01)

Zinc Binds to RRM2 Peptide of TDP-43
by: Andrey V. Golovin, et al.
Published: (2020-11-01)

TDP-43 pathology in chronic traumatic encephalopathy
by: Barnes, Douglas
Published: (2016)

ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration
by: Seiji Watanabe, et al.
Published: (2020-01-01)

TDP-43 and Limbic-Predominant Age-Related TDP-43 Encephalopathy
by: Lumi Zhang, et al.
Published: (2020-01-01)

Optogenetic TDP-43 nucleation induces persistent insoluble species and progressive motor dysfunction in vivo
by: Charlton G. Otte, et al.
Published: (2020-12-01)

Tar DNA-binding protein-43 (TDP-43) regulates axon growth in vitro and in vivo
by: Vineeta Bhasker Tripathi, et al.
Published: (2014-05-01)

Mechanisms of TDP-43 Proteinopathy Onset and Propagation
by: Han-Jou Chen, et al.
Published: (2021-06-01)

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
by: Manami Deshimaru, et al.
Published: (2021-04-01)

Elucidating the Role of TDP-43 in the Pathogenesis of Amyotrophic Lateral Sclerosis
by: Jauregui, Miluska Ingrid
Published: (2012)

Elucidating the Role of TDP-43 in the Pathogenesis of Amyotrophic Lateral Sclerosis
by: Jauregui, Miluska Ingrid
Published: (2012)

Attempted syntheses in the adamantane series /
by: Lowrie, Harman Smith
Published: (1952)

70th Anniversary of the First Synthesis of Adamantane
by: Škorić, I., et al.
Published: (2011-12-01)

The study of highly strained cyclopropyl adamantane compounds with emphasis on their radical copolymerizations with oxygen
by: Schmidt, Justin Orvel
Published: (2011)

Comparative effectiveness research on incision healing after lumbar spinal surgery with different TDP irradiation durations
by: Xiao Feng, et al.
Published: (2018-12-01)

The Pathobiology of TDP-43 C-Terminal Fragments in ALS and FTLD
by: Britt A. Berning, et al.
Published: (2019-04-01)

TDP-43: From Alzheimer’s Disease to Limbic-Predominant Age-Related TDP-43 Encephalopathy
by: Wendi Huang, et al.
Published: (2020-02-01)

The role of TDP-43 mislocalization in amyotrophic lateral sclerosis
by: Terry R. Suk, et al.
Published: (2020-08-01)

TDP-43 regulates cancer-associated microRNAs
by: Xiaowei Chen, et al.
Published: (2017-09-01)

Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies
by: Yohei Iguchi, et al.
Published: (2012-03-01)

Progranulin reduces insoluble TDP-43 levels, slows down axonal degeneration and prolongs survival in mutant TDP-43 mice
by: Sander Beel, et al.
Published: (2018-10-01)

Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation
by: Nikita Fernandes, et al.
Published: (2020-09-01)

Molecular Neuropathology of TDP-43 Proteinopathies
by: Manuela Neumann
Published: (2009-01-01)

Quantitative analysis of cryptic splicing associated with TDP-43 depletion
by: Jack Humphrey, et al.
Published: (2017-05-01)

Theoretical Study on Molecular Structure and Electronic Properties of New 1,3-Diaza-adamantan-6-ones Derivatives
by: Haithem Abdulhasan, et al.
Published: (2020-05-01)

Conditioned Medium from Cells Overexpressing TDP-43 Alters the Metabolome of Recipient Cells
by: Rudolf Hergesheimer, et al.
Published: (2020-09-01)

Transcriptomic Analysis of Zebrafish TDP-43 Transgenic Lines
by: Alexandra Lissouba, et al.
Published: (2018-12-01)