Peripapillary Retinal Vascular Involvement in Early Post-COVID-19 Patients
The ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2′s) to cause multi-organ ischemia and coronavirus-induced posterior segment eye diseases in mammals gave concern about potential sight-threatening ischemia in post coronavirus disease 2019 patients. The radial peripapillary ca...
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doaj-e8e8dc6a08d94218945193447e93289b2020-11-25T02:30:43ZengMDPI AGJournal of Clinical Medicine2077-03832020-09-0192895289510.3390/jcm9092895Peripapillary Retinal Vascular Involvement in Early Post-COVID-19 PatientsAlfonso Savastano0Emanuele Crincoli1Maria Cristina Savastano2Saad Younis3Gloria Gambini4Umberto De Vico5Grazia Maria Cozzupoli6Carola Culiersi7Stanislao Rizzo8Gemelli Against COVID-19 Post-Acute Care Study Group9Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00196 Rome, ItalyOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00196 Rome, ItalyOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00196 Rome, ItalyDepartment of Ophthalmology, Western Eye Hospital, Imperial College Healthcare NHS Trust, London NW1 5QH, UKOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00196 Rome, ItalyOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00196 Rome, ItalyOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00196 Rome, ItalyOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00196 Rome, ItalyOphthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00196 Rome, ItalyDepartment of Ophthalmology, Catholic University of “Sacro Cuore”, 00168 Rome, ItalyThe ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2′s) to cause multi-organ ischemia and coronavirus-induced posterior segment eye diseases in mammals gave concern about potential sight-threatening ischemia in post coronavirus disease 2019 patients. The radial peripapillary capillary plexus (RPCP) is a sensitive target due to the important role in the vascular supply of the peripapillary retinal nerve fiber layer (RNFL). Eighty patients one month after SARS-CoV-2 infection and 30 healthy patients were selected to undergo structural OCT (optical coherence tomography) and OCTA (optical coherence tomography angiography) exams. Primary outcome was a difference in RPCP perfusion density (RPCP-PD) and RPCP flow index (RPCP-FI). No significant difference was observed in age, sex, intraocular pressure (IOP) and prevalence of myopia. RPCP-PD was lower in post SARS-CoV-2 patients compared to controls. Within the post-COVID-19 group, patients with systemic arterial hypertension had lower RPCP-FI and age was inversely correlated to both RPCP-FI and RPCP-PD. Patients treated with lopinavir + ritonavir or antiplatelet therapy during admission had lower RPCP-FI and RPCP-PD. RNFL average thickness was linearly correlated to RPCP-FI and RPCP-PD within post-COVID-19 group. Future studies will be needed to address the hypothesis of a microvascular retinal impairment in individuals who recovered from SARS-CoV-2 infection.https://www.mdpi.com/2077-0383/9/9/2895OCT angiographyperipapillary capillary perfusionpersonalized medicineSARS-CoV-2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Alfonso Savastano Emanuele Crincoli Maria Cristina Savastano Saad Younis Gloria Gambini Umberto De Vico Grazia Maria Cozzupoli Carola Culiersi Stanislao Rizzo Gemelli Against COVID-19 Post-Acute Care Study Group |
spellingShingle |
Alfonso Savastano Emanuele Crincoli Maria Cristina Savastano Saad Younis Gloria Gambini Umberto De Vico Grazia Maria Cozzupoli Carola Culiersi Stanislao Rizzo Gemelli Against COVID-19 Post-Acute Care Study Group Peripapillary Retinal Vascular Involvement in Early Post-COVID-19 Patients Journal of Clinical Medicine OCT angiography peripapillary capillary perfusion personalized medicine SARS-CoV-2 |
author_facet |
Alfonso Savastano Emanuele Crincoli Maria Cristina Savastano Saad Younis Gloria Gambini Umberto De Vico Grazia Maria Cozzupoli Carola Culiersi Stanislao Rizzo Gemelli Against COVID-19 Post-Acute Care Study Group |
author_sort |
Alfonso Savastano |
title |
Peripapillary Retinal Vascular Involvement in Early Post-COVID-19 Patients |
title_short |
Peripapillary Retinal Vascular Involvement in Early Post-COVID-19 Patients |
title_full |
Peripapillary Retinal Vascular Involvement in Early Post-COVID-19 Patients |
title_fullStr |
Peripapillary Retinal Vascular Involvement in Early Post-COVID-19 Patients |
title_full_unstemmed |
Peripapillary Retinal Vascular Involvement in Early Post-COVID-19 Patients |
title_sort |
peripapillary retinal vascular involvement in early post-covid-19 patients |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-09-01 |
description |
The ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2′s) to cause multi-organ ischemia and coronavirus-induced posterior segment eye diseases in mammals gave concern about potential sight-threatening ischemia in post coronavirus disease 2019 patients. The radial peripapillary capillary plexus (RPCP) is a sensitive target due to the important role in the vascular supply of the peripapillary retinal nerve fiber layer (RNFL). Eighty patients one month after SARS-CoV-2 infection and 30 healthy patients were selected to undergo structural OCT (optical coherence tomography) and OCTA (optical coherence tomography angiography) exams. Primary outcome was a difference in RPCP perfusion density (RPCP-PD) and RPCP flow index (RPCP-FI). No significant difference was observed in age, sex, intraocular pressure (IOP) and prevalence of myopia. RPCP-PD was lower in post SARS-CoV-2 patients compared to controls. Within the post-COVID-19 group, patients with systemic arterial hypertension had lower RPCP-FI and age was inversely correlated to both RPCP-FI and RPCP-PD. Patients treated with lopinavir + ritonavir or antiplatelet therapy during admission had lower RPCP-FI and RPCP-PD. RNFL average thickness was linearly correlated to RPCP-FI and RPCP-PD within post-COVID-19 group. Future studies will be needed to address the hypothesis of a microvascular retinal impairment in individuals who recovered from SARS-CoV-2 infection. |
topic |
OCT angiography peripapillary capillary perfusion personalized medicine SARS-CoV-2 |
url |
https://www.mdpi.com/2077-0383/9/9/2895 |
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