Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease.
Impaired olfaction is an early pre-motor symptom of Parkinson's disease. The neuropathology underlying olfactory dysfunction in Parkinson's disease is unknown, however α-synuclein accumulation/aggregation and altered neurogenesis might play a role. We characterized olfactory deficits in a...
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doaj-e8efaf418dac492aae7ce80a13b31c392020-11-24T20:45:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0184e6069110.1371/journal.pone.0060691Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease.Géraldine H PetitElijahu BerkovichMark HickeryPekka KallunkiKarina FogCheryl Fitzer-AttasPatrik BrundinImpaired olfaction is an early pre-motor symptom of Parkinson's disease. The neuropathology underlying olfactory dysfunction in Parkinson's disease is unknown, however α-synuclein accumulation/aggregation and altered neurogenesis might play a role. We characterized olfactory deficits in a transgenic mouse model of Parkinson's disease expressing human wild-type α-synuclein under the control of the mouse α-synuclein promoter. Preliminary clinical observations suggest that rasagiline, a monoamine oxidase-B inhibitor, improves olfaction in Parkinson's disease. We therefore examined whether rasagiline ameliorates olfactory deficits in this Parkinson's disease model and investigated the role of olfactory bulb neurogenesis. α-Synuclein mice were progressively impaired in their ability to detect odors, to discriminate between odors, and exhibited alterations in short-term olfactory memory. Rasagiline treatment rescued odor detection and odor discrimination abilities. However, rasagiline did not affect short-term olfactory memory. Finally, olfactory changes were not coupled to alterations in olfactory bulb neurogenesis. We conclude that rasagiline reverses select olfactory deficits in a transgenic mouse model of Parkinson's disease. The findings correlate with preliminary clinical observations suggesting that rasagiline ameliorates olfactory deficits in Parkinson's disease.http://europepmc.org/articles/PMC3616111?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Géraldine H Petit Elijahu Berkovich Mark Hickery Pekka Kallunki Karina Fog Cheryl Fitzer-Attas Patrik Brundin |
spellingShingle |
Géraldine H Petit Elijahu Berkovich Mark Hickery Pekka Kallunki Karina Fog Cheryl Fitzer-Attas Patrik Brundin Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease. PLoS ONE |
author_facet |
Géraldine H Petit Elijahu Berkovich Mark Hickery Pekka Kallunki Karina Fog Cheryl Fitzer-Attas Patrik Brundin |
author_sort |
Géraldine H Petit |
title |
Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease. |
title_short |
Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease. |
title_full |
Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease. |
title_fullStr |
Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease. |
title_full_unstemmed |
Rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of Parkinson's disease. |
title_sort |
rasagiline ameliorates olfactory deficits in an alpha-synuclein mouse model of parkinson's disease. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
Impaired olfaction is an early pre-motor symptom of Parkinson's disease. The neuropathology underlying olfactory dysfunction in Parkinson's disease is unknown, however α-synuclein accumulation/aggregation and altered neurogenesis might play a role. We characterized olfactory deficits in a transgenic mouse model of Parkinson's disease expressing human wild-type α-synuclein under the control of the mouse α-synuclein promoter. Preliminary clinical observations suggest that rasagiline, a monoamine oxidase-B inhibitor, improves olfaction in Parkinson's disease. We therefore examined whether rasagiline ameliorates olfactory deficits in this Parkinson's disease model and investigated the role of olfactory bulb neurogenesis. α-Synuclein mice were progressively impaired in their ability to detect odors, to discriminate between odors, and exhibited alterations in short-term olfactory memory. Rasagiline treatment rescued odor detection and odor discrimination abilities. However, rasagiline did not affect short-term olfactory memory. Finally, olfactory changes were not coupled to alterations in olfactory bulb neurogenesis. We conclude that rasagiline reverses select olfactory deficits in a transgenic mouse model of Parkinson's disease. The findings correlate with preliminary clinical observations suggesting that rasagiline ameliorates olfactory deficits in Parkinson's disease. |
url |
http://europepmc.org/articles/PMC3616111?pdf=render |
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