The Study on Acute·Subacute Toxicity of Juglandis Semen Herbal-acupuncture(JsD).
Objective: This study was purposed to investigate the acute·subacute toxicity of Herbal acupuncture with Juglandis Semen(JsD) in mice and rats. Methods: Balb/c mice were injected intraperitoneally with JsD for LD50 and acute toxicity test. Sprague-Dawley rats were injected intraperitoneally with Js...
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Korean Pharmacopuncture Institute
2001-12-01
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Online Access: | http://dx.doi.org/10.3831/KPI.2001.4.3.085 |
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doaj-e8f12b124558496a9d54b5d84ee0fade2020-11-25T02:08:03ZengKorean Pharmacopuncture InstituteJournal of Pharmacopuncture2093-69662234-68562001-12-0143859210.3831/KPI.2001.4.3.085The Study on Acute·Subacute Toxicity of Juglandis Semen Herbal-acupuncture(JsD).Kang Kye-SungKwon Gi Rok 0Dept. of Acu. & Mox., college of Oriental Medicine, Sang Ji UNIVObjective: This study was purposed to investigate the acute·subacute toxicity of Herbal acupuncture with Juglandis Semen(JsD) in mice and rats. Methods: Balb/c mice were injected intraperitoneally with JsD for LD50 and acute toxicity test. Sprague-Dawley rats were injected intraperitoneally with JsD for subacute toxicity test. Results: The results obtained were summarized as follows; 1. LD50 was uncountable as could not find the expired of treat group. 2. The clinical signs and body weight changes of mice treated with 0.2cc, 0.4cc JsD were not affected during the acute toxicity test. 3. In acute toxicity test of serum biochemical values of mice, total protein was increased in treat-1 group, compared with normal group, and total cholesterol was increased in treat-2 group, compared with normal group.(P<0.05) 4. In subacute toxicity test, main toxic syndrome was not found. 5. The body weight was decreased in treat-2 group, compared with normal group and relative liver weight was decreased in treat-1, 2 group, compared with normal group in subacute toxicity test.(P<0.05) 6. In subacute toxicity test, WBC, MCH, MCHC were decreased in treat-2 group and RBC was increased in treat-2 group, compared with normal group in complete blood count test.(P<0.05) 7. In subacute toxicity test, treat groups were not changed serum biochemical values of rats, compared with noraml group.(P<0.05) Conclusions: According to the results, Herbal-acupuncture with Juglandis Semen caused no toxicity. http://dx.doi.org/10.3831/KPI.2001.4.3.085Juglandis SemenHerbal-acupunctureLD50Acute toxicitySubacute toxicity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kang Kye-Sung Kwon Gi Rok |
spellingShingle |
Kang Kye-Sung Kwon Gi Rok The Study on Acute·Subacute Toxicity of Juglandis Semen Herbal-acupuncture(JsD). Journal of Pharmacopuncture Juglandis Semen Herbal-acupuncture LD50 Acute toxicity Subacute toxicity |
author_facet |
Kang Kye-Sung Kwon Gi Rok |
author_sort |
Kang Kye-Sung |
title |
The Study on Acute·Subacute Toxicity of Juglandis Semen Herbal-acupuncture(JsD). |
title_short |
The Study on Acute·Subacute Toxicity of Juglandis Semen Herbal-acupuncture(JsD). |
title_full |
The Study on Acute·Subacute Toxicity of Juglandis Semen Herbal-acupuncture(JsD). |
title_fullStr |
The Study on Acute·Subacute Toxicity of Juglandis Semen Herbal-acupuncture(JsD). |
title_full_unstemmed |
The Study on Acute·Subacute Toxicity of Juglandis Semen Herbal-acupuncture(JsD). |
title_sort |
study on acute·subacute toxicity of juglandis semen herbal-acupuncture(jsd). |
publisher |
Korean Pharmacopuncture Institute |
series |
Journal of Pharmacopuncture |
issn |
2093-6966 2234-6856 |
publishDate |
2001-12-01 |
description |
Objective: This study was purposed to investigate the acute·subacute toxicity of Herbal acupuncture with Juglandis Semen(JsD) in mice and rats.
Methods: Balb/c mice were injected intraperitoneally with JsD for LD50 and acute toxicity test. Sprague-Dawley rats were injected intraperitoneally with JsD for subacute toxicity test.
Results: The results obtained were summarized as follows;
1. LD50 was uncountable as could not find the expired of treat group.
2. The clinical signs and body weight changes of mice treated with 0.2cc, 0.4cc JsD were not affected during the acute toxicity test.
3. In acute toxicity test of serum biochemical values of mice, total protein was increased in treat-1 group, compared with normal group, and total cholesterol was increased in treat-2 group, compared with normal group.(P<0.05)
4. In subacute toxicity test, main toxic syndrome was not found.
5. The body weight was decreased in treat-2 group, compared with normal group and relative liver weight was decreased in treat-1, 2 group, compared with normal group in subacute toxicity test.(P<0.05)
6. In subacute toxicity test, WBC, MCH, MCHC were decreased in treat-2 group and RBC was increased in treat-2 group, compared with normal group in complete blood count test.(P<0.05)
7. In subacute toxicity test, treat groups were not changed serum biochemical values of rats, compared with noraml group.(P<0.05)
Conclusions: According to the results, Herbal-acupuncture with Juglandis Semen caused no toxicity. |
topic |
Juglandis Semen Herbal-acupuncture LD50 Acute toxicity Subacute toxicity |
url |
http://dx.doi.org/10.3831/KPI.2001.4.3.085 |
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