Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier
Yongjiu Lv,* Jingjing Li,* Huali Chen, Yan Bai, Liangke Zhang Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing, China *These authors contributed equally to thi...
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doaj-e8f7d655d6764095a10f5518349c1a6d2020-11-24T23:34:36ZengDove Medical PressInternational Journal of Nanomedicine1178-20132017-06-01Volume 124361437033245Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrierLv YLi JChen HBai YZhang LYongjiu Lv,* Jingjing Li,* Huali Chen, Yan Bai, Liangke Zhang Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing, China *These authors contributed equally to this work Abstract: In this study, a glycyrrhetinic acid-functionalized mesoporous silica nanoparticle (MSN-GA) was prepared for active tumor targeting. MSN-GA exhibited satisfactory loading capacity for insoluble drugs, uniform size distribution, and specific tumor cell targeting. Glycyrrhetinic acid, a hepatocellular carcinoma-targeting group, was covalently decorated on the surface of MSN via an amido bond. The successful synthesis of MSN-GA was validated by the results of Fourier transform infrared spectroscopy, transmission electron microscopy (TEM), and zeta potential measurement. TEM images revealed the spherical morphology and uniform size distribution of the naked MSN and MSN-GA. Curcumin (CUR), an insoluble model drug, was loaded into MSN-GA (denoted as MSN-GA-CUR) with a high-loading capacity (8.78%±1.24%). The results of the in vitro cellular experiment demonstrated that MSN-GA-CUR significantly enhanced cytotoxicity and cellular uptake toward hepatocellular carcinoma (HepG2) cells via a specific GA receptor-mediated endocytosis mechanism. The results of this study provide a promising nanoplatform for the targeting of hepatocellular carcinoma. Keywords: active tumor targeting, silica nanoparticle, drug loading capacity, HepG2 cellshttps://www.dovepress.com/glycyrrhetinic-acid-functionalized-mesoporous-silica-nanoparticles-as--peer-reviewed-article-IJNGlycyrrhetinic acidMesoporous silica nanoparticleTumor targetingHepG2 cells |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lv Y Li J Chen H Bai Y Zhang L |
spellingShingle |
Lv Y Li J Chen H Bai Y Zhang L Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier International Journal of Nanomedicine Glycyrrhetinic acid Mesoporous silica nanoparticle Tumor targeting HepG2 cells |
author_facet |
Lv Y Li J Chen H Bai Y Zhang L |
author_sort |
Lv Y |
title |
Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier |
title_short |
Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier |
title_full |
Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier |
title_fullStr |
Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier |
title_full_unstemmed |
Glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier |
title_sort |
glycyrrhetinic acid-functionalized mesoporous silica nanoparticles as hepatocellular carcinoma-targeted drug carrier |
publisher |
Dove Medical Press |
series |
International Journal of Nanomedicine |
issn |
1178-2013 |
publishDate |
2017-06-01 |
description |
Yongjiu Lv,* Jingjing Li,* Huali Chen, Yan Bai, Liangke Zhang Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing Research Center for Pharmaceutical Engineering, College of Pharmacy, Chongqing Medical University, Chongqing, China *These authors contributed equally to this work Abstract: In this study, a glycyrrhetinic acid-functionalized mesoporous silica nanoparticle (MSN-GA) was prepared for active tumor targeting. MSN-GA exhibited satisfactory loading capacity for insoluble drugs, uniform size distribution, and specific tumor cell targeting. Glycyrrhetinic acid, a hepatocellular carcinoma-targeting group, was covalently decorated on the surface of MSN via an amido bond. The successful synthesis of MSN-GA was validated by the results of Fourier transform infrared spectroscopy, transmission electron microscopy (TEM), and zeta potential measurement. TEM images revealed the spherical morphology and uniform size distribution of the naked MSN and MSN-GA. Curcumin (CUR), an insoluble model drug, was loaded into MSN-GA (denoted as MSN-GA-CUR) with a high-loading capacity (8.78%±1.24%). The results of the in vitro cellular experiment demonstrated that MSN-GA-CUR significantly enhanced cytotoxicity and cellular uptake toward hepatocellular carcinoma (HepG2) cells via a specific GA receptor-mediated endocytosis mechanism. The results of this study provide a promising nanoplatform for the targeting of hepatocellular carcinoma. Keywords: active tumor targeting, silica nanoparticle, drug loading capacity, HepG2 cells |
topic |
Glycyrrhetinic acid Mesoporous silica nanoparticle Tumor targeting HepG2 cells |
url |
https://www.dovepress.com/glycyrrhetinic-acid-functionalized-mesoporous-silica-nanoparticles-as--peer-reviewed-article-IJN |
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