The clinical value of long - term electroencephalogram (EEG) in seizure - free populations: implications from a cross-sectional study
Abstract Backgroud This study aimed to explore the clinical value of long - term electroencephalogram (LTM EEG) in seizure-free individuals taking antiepileptic drugs (AEDs) for more than 2 years. We try to look for clinical factors associated with epileptiform activity on LTM EEG in seizure free pa...
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doaj-e8fc862cb2744234ae57ddd15e8702042020-11-25T02:28:12ZengBMCBMC Neurology1471-23772020-03-012011710.1186/s12883-019-1521-1The clinical value of long - term electroencephalogram (EEG) in seizure - free populations: implications from a cross-sectional studyTang Xinghua0Li Lin1Fan Qinyi2Wei Yarong3Pu Zheng4Liu Zhenguo5Department of Neurology, Xinhua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Neurology, Xinhua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Neurology, Xinhua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Neurology, Xinhua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Neurology, Xinhua Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Neurology, Xinhua Hospital, Shanghai Jiao Tong University School of MedicineAbstract Backgroud This study aimed to explore the clinical value of long - term electroencephalogram (LTM EEG) in seizure-free individuals taking antiepileptic drugs (AEDs) for more than 2 years. We try to look for clinical factors associated with epileptiform activity on LTM EEG in seizure free patients. We hope that the detection of epileptiform activity by the LTM EEG recording can develop the better treatment strategy. Methods The LTM EEG recordings of 770 individuals with a definite diagnosis of epilepsy were assessed. Two hundred sixty-two individuals accorded with the inclusion criteria and exclusion criteria. We collect the demographic and clinical information and LTM EEG data of these 262 individuals. We analysed the data by one-way analysis of variance and Cox proportional hazards models. Results We found that more epileptiform activity were found with LTM EEG recording than regular EEG recording in seizure-free individuals. We found several clinical factors could be associated with epileptiform activity on LTM EEG in seizure free patients by a one-way analysis: symptomatic or cryptogenic epilepsy [hazard ratio (HR) = 2.6], history of cerebral trauma (HR = 7.5), and abnormal imaging findings (HR = 3.1). The following factors suggested a correlation between history of cerebral trauma (HR = 2.4) and history of cerebral surgery (HR = 3.4) with epileptiform activity on LTM EEG presentation by multivariate logistic regression analysis. Conclusions The study indicated a correlation of a number of factors with abnormal LTM EEG presentation: symptomatic or cryptogenic epilepsy, history of cerebral trauma, history of cerebral surgery, and abnormal imaging findings. The LTM EEG recording may help find epileptiform activity in high risk seizure-free individuals. The individuals need be reevaluated the therapeutic strateagies, and increase the hope to reach real seizure-free.http://link.springer.com/article/10.1186/s12883-019-1521-1EpilepsyLTM EEGSeizure-freeEpileptiform activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tang Xinghua Li Lin Fan Qinyi Wei Yarong Pu Zheng Liu Zhenguo |
spellingShingle |
Tang Xinghua Li Lin Fan Qinyi Wei Yarong Pu Zheng Liu Zhenguo The clinical value of long - term electroencephalogram (EEG) in seizure - free populations: implications from a cross-sectional study BMC Neurology Epilepsy LTM EEG Seizure-free Epileptiform activity |
author_facet |
Tang Xinghua Li Lin Fan Qinyi Wei Yarong Pu Zheng Liu Zhenguo |
author_sort |
Tang Xinghua |
title |
The clinical value of long - term electroencephalogram (EEG) in seizure - free populations: implications from a cross-sectional study |
title_short |
The clinical value of long - term electroencephalogram (EEG) in seizure - free populations: implications from a cross-sectional study |
title_full |
The clinical value of long - term electroencephalogram (EEG) in seizure - free populations: implications from a cross-sectional study |
title_fullStr |
The clinical value of long - term electroencephalogram (EEG) in seizure - free populations: implications from a cross-sectional study |
title_full_unstemmed |
The clinical value of long - term electroencephalogram (EEG) in seizure - free populations: implications from a cross-sectional study |
title_sort |
clinical value of long - term electroencephalogram (eeg) in seizure - free populations: implications from a cross-sectional study |
publisher |
BMC |
series |
BMC Neurology |
issn |
1471-2377 |
publishDate |
2020-03-01 |
description |
Abstract Backgroud This study aimed to explore the clinical value of long - term electroencephalogram (LTM EEG) in seizure-free individuals taking antiepileptic drugs (AEDs) for more than 2 years. We try to look for clinical factors associated with epileptiform activity on LTM EEG in seizure free patients. We hope that the detection of epileptiform activity by the LTM EEG recording can develop the better treatment strategy. Methods The LTM EEG recordings of 770 individuals with a definite diagnosis of epilepsy were assessed. Two hundred sixty-two individuals accorded with the inclusion criteria and exclusion criteria. We collect the demographic and clinical information and LTM EEG data of these 262 individuals. We analysed the data by one-way analysis of variance and Cox proportional hazards models. Results We found that more epileptiform activity were found with LTM EEG recording than regular EEG recording in seizure-free individuals. We found several clinical factors could be associated with epileptiform activity on LTM EEG in seizure free patients by a one-way analysis: symptomatic or cryptogenic epilepsy [hazard ratio (HR) = 2.6], history of cerebral trauma (HR = 7.5), and abnormal imaging findings (HR = 3.1). The following factors suggested a correlation between history of cerebral trauma (HR = 2.4) and history of cerebral surgery (HR = 3.4) with epileptiform activity on LTM EEG presentation by multivariate logistic regression analysis. Conclusions The study indicated a correlation of a number of factors with abnormal LTM EEG presentation: symptomatic or cryptogenic epilepsy, history of cerebral trauma, history of cerebral surgery, and abnormal imaging findings. The LTM EEG recording may help find epileptiform activity in high risk seizure-free individuals. The individuals need be reevaluated the therapeutic strateagies, and increase the hope to reach real seizure-free. |
topic |
Epilepsy LTM EEG Seizure-free Epileptiform activity |
url |
http://link.springer.com/article/10.1186/s12883-019-1521-1 |
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