Therapeutic Effect of Conjugated Linoleic Acid Supplementation on Moderate Acne
Background & objectives: Acne Vulgaris is a chronic inflammation of pilosebaceous glands. Some studies have indicated the significant decrease of linoleic acid in the sebum composition of the patients with acne. The aim of this study was to determine the probable therapeutic effects of linoleic...
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Ardabil University of Medical Sciences
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doaj-e9095153629d4502b3dd2de1a5042c342020-11-25T03:18:57ZfasArdabil University of Medical SciencesJournal of Ardabil University of Medical Sciences2228-72802228-72992017-07-01172189197Therapeutic Effect of Conjugated Linoleic Acid Supplementation on Moderate AcneHasan Edalatkhah0Nazila Rahnema Tareghi1Saeeid Sadeghieh Ahari2Ali Nemati3 1. Department of Dermatology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran 2. General practitioner, Ardabil University of Medical Sciences, Ardabil, Iran 3. Social determinants of Health Research Center, Ardabil University of Medical Sciences, Ardabil, Iran 4. Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran. Background & objectives: Acne Vulgaris is a chronic inflammation of pilosebaceous glands. Some studies have indicated the significant decrease of linoleic acid in the sebum composition of the patients with acne. The aim of this study was to determine the probable therapeutic effects of linoleic acid on moderate acne. Methods: In a double-blind randomized clinical trial, 40 women with moderate acne were divided into two groups, each group with 20 each with 20 samples. After recording the nutritional and demographic factors, the case group received, 100 mg oral doxycycline daily plus 3 gr conjugated linoleic acid and the control group received 100 mg doxycycline daily plus 4-3 oral paraffin capsules as placebo for one month. The number of acne lesions were counted before and after treatment and the mean of Acne Severity Index (ASI) and Global Acne Grading System (GAGS) were determined for each group. The collected data were analyzed by SPSS software using chi-square, independent t-test and paired t-test. Results: The mean age was 22.8±5.5, in the case group and21.7±5.1 in placebo group indicating no statistically significant deference (p=0.51). At the end of treatment there was no statistically significant deference between the two groups in decreasing acne (p=0.31). During the treatment, ASI reduced from 129.5±13 to 77±11.6 in the case group and from 132±18.6 to 67.5±11.6 in the placebo group, –but there was no statistically significant deference between the two groups (p=0.37). Conclusion: It seems using 3 gr oral conjugated linoleic acid daily for 1 month has no effect on remission of acne.http://jarums.arums.ac.ir/browse.php?a_code=A-10-607-62&slc_lang=en&sid=1Acne Vulgaris Conjugated Linoleic Acid Placebo Iran |
collection |
DOAJ |
language |
fas |
format |
Article |
sources |
DOAJ |
author |
Hasan Edalatkhah Nazila Rahnema Tareghi Saeeid Sadeghieh Ahari Ali Nemati |
spellingShingle |
Hasan Edalatkhah Nazila Rahnema Tareghi Saeeid Sadeghieh Ahari Ali Nemati Therapeutic Effect of Conjugated Linoleic Acid Supplementation on Moderate Acne Journal of Ardabil University of Medical Sciences Acne Vulgaris Conjugated Linoleic Acid Placebo Iran |
author_facet |
Hasan Edalatkhah Nazila Rahnema Tareghi Saeeid Sadeghieh Ahari Ali Nemati |
author_sort |
Hasan Edalatkhah |
title |
Therapeutic Effect of Conjugated Linoleic Acid Supplementation on Moderate Acne |
title_short |
Therapeutic Effect of Conjugated Linoleic Acid Supplementation on Moderate Acne |
title_full |
Therapeutic Effect of Conjugated Linoleic Acid Supplementation on Moderate Acne |
title_fullStr |
Therapeutic Effect of Conjugated Linoleic Acid Supplementation on Moderate Acne |
title_full_unstemmed |
Therapeutic Effect of Conjugated Linoleic Acid Supplementation on Moderate Acne |
title_sort |
therapeutic effect of conjugated linoleic acid supplementation on moderate acne |
publisher |
Ardabil University of Medical Sciences |
series |
Journal of Ardabil University of Medical Sciences |
issn |
2228-7280 2228-7299 |
publishDate |
2017-07-01 |
description |
Background & objectives: Acne Vulgaris is a chronic inflammation of pilosebaceous glands. Some studies have indicated the significant decrease of linoleic acid in the sebum composition of the patients with acne. The aim of this study was to determine the probable therapeutic effects of linoleic acid on moderate acne.
Methods: In a double-blind randomized clinical trial, 40 women with moderate acne were divided into two groups, each group with 20 each with 20 samples. After recording the nutritional and demographic factors, the case group received, 100 mg oral doxycycline daily plus 3 gr conjugated linoleic acid and the control group received 100 mg doxycycline daily plus 4-3 oral paraffin capsules as placebo for one month. The number of acne lesions were counted before and after treatment and the mean of Acne Severity Index (ASI) and Global Acne Grading System (GAGS) were determined for each group. The collected data were analyzed by SPSS software using chi-square, independent t-test and paired t-test.
Results: The mean age was 22.8±5.5, in the case group and21.7±5.1 in placebo group indicating no statistically significant deference (p=0.51). At the end of treatment there was no statistically significant deference between the two groups in decreasing acne (p=0.31). During the treatment, ASI reduced from 129.5±13 to 77±11.6 in the case group and from 132±18.6 to 67.5±11.6 in the placebo group, –but there was no statistically significant deference between the two groups (p=0.37).
Conclusion: It seems using 3 gr oral conjugated linoleic acid daily for 1 month has no effect on remission of acne. |
topic |
Acne Vulgaris Conjugated Linoleic Acid Placebo Iran |
url |
http://jarums.arums.ac.ir/browse.php?a_code=A-10-607-62&slc_lang=en&sid=1 |
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