Expression of PYY, MTL and GAS in serum of IBS patients and their relationship with inflammatory response

• Main Authors: Shu-Bo Pan, Xiao-Hua Shi
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2019-02-01
• Series: Journal of Hainan Medical University
• Online Access: http://www.hnykdxxb.com/PDF/201904/08.pdf

Objective: Expression of PYY, MTL and GAS in serum of IBS patients and their relationship with inflammatory response. Methods: Using 100 IBS patients admitted to our hospital from November 2016 toApril 2018as the observation group and 100 normal persons in the same period as the control group, we observed the levels of serum PYY, MTL, GAS and expression of inflammatory factors in the two groups, and the correlation between different clinical symptoms of the disease group and serum PYY, MTL, GAS. The correlation analysis between serum PYY, MTL, GAS and inflammatory response in patients with disease and the influencing factors of patients with disease. Results: The expression levels of PYY, MTL, GAS and inflammatory factors in patients with diarrhea were significantly higher than those in control group, and the expression levels of PYY, MTL, GAS and inflammatory factors in patients with diarrhea were significantly higher than those in patients with constipation. The expression levels of PYY, MTL and GAS in patients with diarrhea and constipation were negatively correlated. There was a negative correlation between serum inflammatory factors and DIARRHEA-TYPE patients, but no correlation between Constipation-Type patients and inflammatory factors. Serum PYY, MTL and GAS were positively correlated with inflammatory reaction factors TNF-a, IL-6 and IL-8 in DIARRHEA-TYPE patients. Serum PYY, MTL and GAS levels in patients with DIARRHEA-TYPE patients could be regarded as independent risk factors for IBS. Conclusion: The serum levels of PYY, MTL and GAS in patients with diarrhea IBS were positively correlated with the expression of inflammatory factors, which had guiding significance for the diagnosis and treatment of IBS.