Cytotoxic Effects of <em>Phlomis Brevibracteata</em> Turril. on SK-HEP-1 Adenocarcinoma Cell Line
<i>Phlomis </i>is a large genus in the Lamiaceae family with over 100 species distributed throughout Europe, Asia and North Africa. Some species of <i>Phlomis </i>are used in folk medicine as a stimulant, tonic, and for wound healing. Many studies have shown that different &l...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2019-12-01
|
Series: | Proceedings |
Subjects: | |
Online Access: | https://www.mdpi.com/2504-3900/40/1/34 |
id |
doaj-e90e8961c01441b88afe25c35f7ea47b |
---|---|
record_format |
Article |
spelling |
doaj-e90e8961c01441b88afe25c35f7ea47b2020-11-25T00:28:37ZengMDPI AGProceedings2504-39002019-12-014013410.3390/proceedings2019040034proceedings2019040034Cytotoxic Effects of <em>Phlomis Brevibracteata</em> Turril. on SK-HEP-1 Adenocarcinoma Cell LineImge Kunter0Beste Atli1Ezgi Ak2Nesrin Oztinen3Andia Babri4Muberra Kosar5Faculty of Pharmacy, Eastern Mediterranean University, North Cyprus via Mersin 10, 99628 Famagusta, TurkeyFaculty of Pharmacy, Eastern Mediterranean University, North Cyprus via Mersin 10, 99628 Famagusta, TurkeyFaculty of Pharmacy, Eastern Mediterranean University, North Cyprus via Mersin 10, 99628 Famagusta, TurkeyFaculty of Pharmacy, Eastern Mediterranean University, North Cyprus via Mersin 10, 99628 Famagusta, TurkeyFaculty of Pharmacy, Eastern Mediterranean University, North Cyprus via Mersin 10, 99628 Famagusta, TurkeyFaculty of Pharmacy, Eastern Mediterranean University, North Cyprus via Mersin 10, 99628 Famagusta, Turkey<i>Phlomis </i>is a large genus in the Lamiaceae family with over 100 species distributed throughout Europe, Asia and North Africa. Some species of <i>Phlomis </i>are used in folk medicine as a stimulant, tonic, and for wound healing. Many studies have shown that different <i>Phlomis</i> species have anti‐inflammatory, immunosuppressive, free radical scavenging, antimicrobial, anti-ulcerogenic and anti-mutagenic activities. Among these species,<i> Phlomis brevibracteata</i>, Turrill, is an endemic plant which grows in Kyrenia, Karpasia, Nicosia and Limassol regions of Cyprus. In our previous studies, we found that methanol extract (PBM) has anti-carcinogenic activity, in terms of cytotoxicity and 2D motility inhibition. In this study, we tried to find out potential anti-carcinogenic activity of hexane (PBH), ethyl acetate (PBE) and butanol (PBB) sub-crude extracts of the methanol-extracts of the same plant. PBH, PBE and PBB extracts of herbal parts of the plant were used in different concentrations to assess the anti-carcinogenic activity on liver adenocarcinoma cell SK-HEP-1. MTT and wound healing assays were carried out to determine anti-cancinogenic activities. Our findings showed that all three extracts have negative effects on cell viability and motility with different levels. Among these extracts, PBE and PBH extracts were more potent than PBB in terms of IC<sub>50</sub> values.https://www.mdpi.com/2504-3900/40/1/34phlomis brevibracteatask-hep-1 cellsanti-carcinogenic activity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Imge Kunter Beste Atli Ezgi Ak Nesrin Oztinen Andia Babri Muberra Kosar |
spellingShingle |
Imge Kunter Beste Atli Ezgi Ak Nesrin Oztinen Andia Babri Muberra Kosar Cytotoxic Effects of <em>Phlomis Brevibracteata</em> Turril. on SK-HEP-1 Adenocarcinoma Cell Line Proceedings phlomis brevibracteata sk-hep-1 cells anti-carcinogenic activity |
author_facet |
Imge Kunter Beste Atli Ezgi Ak Nesrin Oztinen Andia Babri Muberra Kosar |
author_sort |
Imge Kunter |
title |
Cytotoxic Effects of <em>Phlomis Brevibracteata</em> Turril. on SK-HEP-1 Adenocarcinoma Cell Line |
title_short |
Cytotoxic Effects of <em>Phlomis Brevibracteata</em> Turril. on SK-HEP-1 Adenocarcinoma Cell Line |
title_full |
Cytotoxic Effects of <em>Phlomis Brevibracteata</em> Turril. on SK-HEP-1 Adenocarcinoma Cell Line |
title_fullStr |
Cytotoxic Effects of <em>Phlomis Brevibracteata</em> Turril. on SK-HEP-1 Adenocarcinoma Cell Line |
title_full_unstemmed |
Cytotoxic Effects of <em>Phlomis Brevibracteata</em> Turril. on SK-HEP-1 Adenocarcinoma Cell Line |
title_sort |
cytotoxic effects of <em>phlomis brevibracteata</em> turril. on sk-hep-1 adenocarcinoma cell line |
publisher |
MDPI AG |
series |
Proceedings |
issn |
2504-3900 |
publishDate |
2019-12-01 |
description |
<i>Phlomis </i>is a large genus in the Lamiaceae family with over 100 species distributed throughout Europe, Asia and North Africa. Some species of <i>Phlomis </i>are used in folk medicine as a stimulant, tonic, and for wound healing. Many studies have shown that different <i>Phlomis</i> species have anti‐inflammatory, immunosuppressive, free radical scavenging, antimicrobial, anti-ulcerogenic and anti-mutagenic activities. Among these species,<i> Phlomis brevibracteata</i>, Turrill, is an endemic plant which grows in Kyrenia, Karpasia, Nicosia and Limassol regions of Cyprus. In our previous studies, we found that methanol extract (PBM) has anti-carcinogenic activity, in terms of cytotoxicity and 2D motility inhibition. In this study, we tried to find out potential anti-carcinogenic activity of hexane (PBH), ethyl acetate (PBE) and butanol (PBB) sub-crude extracts of the methanol-extracts of the same plant. PBH, PBE and PBB extracts of herbal parts of the plant were used in different concentrations to assess the anti-carcinogenic activity on liver adenocarcinoma cell SK-HEP-1. MTT and wound healing assays were carried out to determine anti-cancinogenic activities. Our findings showed that all three extracts have negative effects on cell viability and motility with different levels. Among these extracts, PBE and PBH extracts were more potent than PBB in terms of IC<sub>50</sub> values. |
topic |
phlomis brevibracteata sk-hep-1 cells anti-carcinogenic activity |
url |
https://www.mdpi.com/2504-3900/40/1/34 |
work_keys_str_mv |
AT imgekunter cytotoxiceffectsofemphlomisbrevibracteataemturrilonskhep1adenocarcinomacellline AT besteatli cytotoxiceffectsofemphlomisbrevibracteataemturrilonskhep1adenocarcinomacellline AT ezgiak cytotoxiceffectsofemphlomisbrevibracteataemturrilonskhep1adenocarcinomacellline AT nesrinoztinen cytotoxiceffectsofemphlomisbrevibracteataemturrilonskhep1adenocarcinomacellline AT andiababri cytotoxiceffectsofemphlomisbrevibracteataemturrilonskhep1adenocarcinomacellline AT muberrakosar cytotoxiceffectsofemphlomisbrevibracteataemturrilonskhep1adenocarcinomacellline |
_version_ |
1725335189336358912 |