mTOR and Aging: An Old Fashioned Dress
Aging is a physiologic/pathologic process characterized by a progressive impairment of cellular functions, supported by the alterations of several molecular pathways, leading to an increased cell susceptibility to injury. This deterioration is the primary risk factor for several major human patholog...
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doaj-e91ab06901494faabacfd1dca05519182020-11-24T23:54:50ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-06-012011277410.3390/ijms20112774ijms20112774mTOR and Aging: An Old Fashioned DressGiovanni Stallone0Barbara Infante1Concetta Prisciandaro2Giuseppe Grandaliano3Department of Medical and Surgical Sciences, Nephrology, Dialysis and Transplantation Unit, University of Foggia, Viale Luigi Pinto, 1, 71100 Foggia, ItalyDepartment of Medical and Surgical Sciences, Nephrology, Dialysis and Transplantation Unit, University of Foggia, Viale Luigi Pinto, 1, 71100 Foggia, ItalyDepartment of Medical and Surgical Sciences, Nephrology, Dialysis and Transplantation Unit, University of Foggia, Viale Luigi Pinto, 1, 71100 Foggia, ItalyDepartment of Medical and Surgical Sciences, Nephrology, Dialysis and Transplantation Unit, University of Foggia, Viale Luigi Pinto, 1, 71100 Foggia, ItalyAging is a physiologic/pathologic process characterized by a progressive impairment of cellular functions, supported by the alterations of several molecular pathways, leading to an increased cell susceptibility to injury. This deterioration is the primary risk factor for several major human pathologies. Numerous cellular processes, including genomic instability, telomere erosion, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, stem cell exhaustion, and altered intercellular signal transduction represent common denominators of aging in different organisms. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved nutrient sensing protein kinase that regulates growth and metabolism in all eukaryotic cells. Studies in flies, worms, yeast, and mice support the hypothesis that the mTOR signalling network plays a pivotal role in modulating aging. mTOR is emerging as the most robust mediator of the protective effects of various forms of dietary restriction, which has been shown to extend lifespan and slow the onset of age-related diseases across species. Herein we discuss the role of mTor signalling network in the development of classic age-related diseases, focused on cardiovascular system, immune response, and cancer.https://www.mdpi.com/1422-0067/20/11/2774mTORagingcardiovascular systemimmune systemcancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Giovanni Stallone Barbara Infante Concetta Prisciandaro Giuseppe Grandaliano |
spellingShingle |
Giovanni Stallone Barbara Infante Concetta Prisciandaro Giuseppe Grandaliano mTOR and Aging: An Old Fashioned Dress International Journal of Molecular Sciences mTOR aging cardiovascular system immune system cancer |
author_facet |
Giovanni Stallone Barbara Infante Concetta Prisciandaro Giuseppe Grandaliano |
author_sort |
Giovanni Stallone |
title |
mTOR and Aging: An Old Fashioned Dress |
title_short |
mTOR and Aging: An Old Fashioned Dress |
title_full |
mTOR and Aging: An Old Fashioned Dress |
title_fullStr |
mTOR and Aging: An Old Fashioned Dress |
title_full_unstemmed |
mTOR and Aging: An Old Fashioned Dress |
title_sort |
mtor and aging: an old fashioned dress |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-06-01 |
description |
Aging is a physiologic/pathologic process characterized by a progressive impairment of cellular functions, supported by the alterations of several molecular pathways, leading to an increased cell susceptibility to injury. This deterioration is the primary risk factor for several major human pathologies. Numerous cellular processes, including genomic instability, telomere erosion, epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, stem cell exhaustion, and altered intercellular signal transduction represent common denominators of aging in different organisms. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved nutrient sensing protein kinase that regulates growth and metabolism in all eukaryotic cells. Studies in flies, worms, yeast, and mice support the hypothesis that the mTOR signalling network plays a pivotal role in modulating aging. mTOR is emerging as the most robust mediator of the protective effects of various forms of dietary restriction, which has been shown to extend lifespan and slow the onset of age-related diseases across species. Herein we discuss the role of mTor signalling network in the development of classic age-related diseases, focused on cardiovascular system, immune response, and cancer. |
topic |
mTOR aging cardiovascular system immune system cancer |
url |
https://www.mdpi.com/1422-0067/20/11/2774 |
work_keys_str_mv |
AT giovannistallone mtorandaginganoldfashioneddress AT barbarainfante mtorandaginganoldfashioneddress AT concettaprisciandaro mtorandaginganoldfashioneddress AT giuseppegrandaliano mtorandaginganoldfashioneddress |
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1725464651996594176 |