Interplay Between Lipid Metabolism and Autophagy
Autophagy is a self-eating process of using lysosomes to degrade macromolecular substances (e.g., proteins and organelles) that are damaged, degenerated, or aging. Lipid metabolism is the synthesis and degradation of lipids (e.g., triglycerides, steroids, and phospholipids) to generate energy or pro...
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doaj-e91d6dfe563942f682c54f7ab0602fe82020-11-25T02:51:18ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2020-06-01810.3389/fcell.2020.00431543896Interplay Between Lipid Metabolism and AutophagyYangchun Xie0Jingbo Li1Rui Kang2Daolin Tang3Department of Oncology, The Second Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Surgery, UT Southwestern Medical Center, Dallas, TX, United StatesDepartment of Surgery, UT Southwestern Medical Center, Dallas, TX, United StatesDepartment of Surgery, UT Southwestern Medical Center, Dallas, TX, United StatesAutophagy is a self-eating process of using lysosomes to degrade macromolecular substances (e.g., proteins and organelles) that are damaged, degenerated, or aging. Lipid metabolism is the synthesis and degradation of lipids (e.g., triglycerides, steroids, and phospholipids) to generate energy or produce the structural components of cell membranes. There is a complex interplay between lipid metabolism (e.g., digestion, absorption, catabolism, biosynthesis, and peroxidation) and autophagy machinery, leading to the modulation of cell homeostasis, including cell survival and death. In particular, lipid metabolism is involved in the formation of autophagic membrane structures (e.g., phagophores and autophagosomes) during stress. Moreover, autophagy, especially selective autophagy (e.g., lipophagy, ferritinophagy, clockophagy, and mitophagy), promotes lipid catabolism or lipid peroxidation-induced ferroptosis through the degradation of various substances within the cell. A better understanding of the mechanisms of autophagy and possible links to lipid metabolism will undoubtedly promote potential treatments for a variety of diseases.https://www.frontiersin.org/article/10.3389/fcell.2020.00431/fullautophagylipidmetabolismlipophagyferritinophagyclockophagy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yangchun Xie Jingbo Li Rui Kang Daolin Tang |
spellingShingle |
Yangchun Xie Jingbo Li Rui Kang Daolin Tang Interplay Between Lipid Metabolism and Autophagy Frontiers in Cell and Developmental Biology autophagy lipid metabolism lipophagy ferritinophagy clockophagy |
author_facet |
Yangchun Xie Jingbo Li Rui Kang Daolin Tang |
author_sort |
Yangchun Xie |
title |
Interplay Between Lipid Metabolism and Autophagy |
title_short |
Interplay Between Lipid Metabolism and Autophagy |
title_full |
Interplay Between Lipid Metabolism and Autophagy |
title_fullStr |
Interplay Between Lipid Metabolism and Autophagy |
title_full_unstemmed |
Interplay Between Lipid Metabolism and Autophagy |
title_sort |
interplay between lipid metabolism and autophagy |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cell and Developmental Biology |
issn |
2296-634X |
publishDate |
2020-06-01 |
description |
Autophagy is a self-eating process of using lysosomes to degrade macromolecular substances (e.g., proteins and organelles) that are damaged, degenerated, or aging. Lipid metabolism is the synthesis and degradation of lipids (e.g., triglycerides, steroids, and phospholipids) to generate energy or produce the structural components of cell membranes. There is a complex interplay between lipid metabolism (e.g., digestion, absorption, catabolism, biosynthesis, and peroxidation) and autophagy machinery, leading to the modulation of cell homeostasis, including cell survival and death. In particular, lipid metabolism is involved in the formation of autophagic membrane structures (e.g., phagophores and autophagosomes) during stress. Moreover, autophagy, especially selective autophagy (e.g., lipophagy, ferritinophagy, clockophagy, and mitophagy), promotes lipid catabolism or lipid peroxidation-induced ferroptosis through the degradation of various substances within the cell. A better understanding of the mechanisms of autophagy and possible links to lipid metabolism will undoubtedly promote potential treatments for a variety of diseases. |
topic |
autophagy lipid metabolism lipophagy ferritinophagy clockophagy |
url |
https://www.frontiersin.org/article/10.3389/fcell.2020.00431/full |
work_keys_str_mv |
AT yangchunxie interplaybetweenlipidmetabolismandautophagy AT jingboli interplaybetweenlipidmetabolismandautophagy AT ruikang interplaybetweenlipidmetabolismandautophagy AT daolintang interplaybetweenlipidmetabolismandautophagy |
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