The small molecule alpha-synuclein misfolding inhibitor, NPT200-11, produces multiple benefits in an animal model of Parkinson’s disease
Abstract Accumulation of alpha-synuclein (ASYN) in neurons and other CNS cell types may contribute to the underlying pathology of synucleinopathies including Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and Multiple Systems Atrophy (MSA). In support of this hypothesis for PD, ASYN immun...
Main Authors: | Diana L. Price, Maya A. Koike, Asma Khan, Wolfgang Wrasidlo, Edward Rockenstein, Eliezer Masliah, Douglas Bonhaus |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2018-11-01
|
Series: | Scientific Reports |
Subjects: | |
Online Access: | https://doi.org/10.1038/s41598-018-34490-9 |
Similar Items
-
Alpha-Synuclein Pathology Coincides With Increased Number of Early Stage Neural Progenitors in the Adult Hippocampus
by: Hannah Bender, et al.
Published: (2021-07-01) -
The Cognitive Profile of Mild Cognitive Impairment Due to Dementia With Lewy Bodies—An Updated Review
by: Mathilde Suhr Hemminghyth, et al.
Published: (2020-12-01) -
Role of α- and β-Synucleins in the Axonal Pathology of Parkinson’s Disease and Related Synucleinopathies
by: Akio Sekigawa, et al.
Published: (2015-05-01) -
Import and Export of Misfolded α-Synuclein
by: Lilia Rodriguez, et al.
Published: (2018-05-01) -
PROBABLE DEMENTIA WITH LEWY BODY
by: Irene Davidescu
Published: (2017-03-01)