Interactions of Methylenetetrahydrofolate Reductase C677T Polymorphism with Environmental Factors on Hypertension Susceptibility
Hypertension is considered to be the result of genes, environment, and their interactions. Among them age, sex, tobacco use, alcohol consumption, and being overweight/obesity are well documented environmental determinants, and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is nominat...
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doaj-e9351d2fa9d942449edc3e6af72b2bec2020-11-24T22:25:31ZengMDPI AGInternational Journal of Environmental Research and Public Health1660-46012016-06-0113660110.3390/ijerph13060601ijerph13060601Interactions of Methylenetetrahydrofolate Reductase C677T Polymorphism with Environmental Factors on Hypertension SusceptibilityShujun Fan0Boyi Yang1Xueyuan Zhi2Yanxun Wang3Jian Wei4Quanmei Zheng5Guifan Sun6Environment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, Shenyang 110013, ChinaGuangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-sen University, Guangzhou 510080, ChinaEnvironment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, Shenyang 110013, ChinaDivision of Molecular Preventive Medicine, Shanghai Institute of Targeted Therapy and Molecular Medicine, Shanghai 200433, ChinaBrain Disease Center, Tianjin Dagang Oil Field General Hospital, Tianjin 300280, ChinaEnvironment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, Shenyang 110013, ChinaEnvironment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, Shenyang 110013, ChinaHypertension is considered to be the result of genes, environment, and their interactions. Among them age, sex, tobacco use, alcohol consumption, and being overweight/obesity are well documented environmental determinants, and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is nominated as a potential genetic candidate. However, the synergistic effect of the MTHFR C677T polymorphism with these environmental factors on the risk of hypertension has received little attention. The aim of this study was to explore the associations of the MTHFR C677T polymorphism, environmental factors, and their interactions with hypertension predisposition in a Northern Chinese Han population. A total of 708 participants were enrolled in the study. The genotypes of the MTHFR C677T were determined by a TaqMan assay. We found that participants of an older age, being overweight/obesity, with a smoking habit, drinking habit, or carrying the 677T allele were at an increased risk of hypertension. Additionally, there existed marginally significant interactions of the polymorphism with age and overweight/obesity. However, future large, well-designed studies in Chinese and other populations, as well as mechanistic studies, are still needed to validate our findings, especially considering that the interactions observed in our study were only marginally significant.http://www.mdpi.com/1660-4601/13/6/601environmental factorshypertensioninteractionMTHFR C677T |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shujun Fan Boyi Yang Xueyuan Zhi Yanxun Wang Jian Wei Quanmei Zheng Guifan Sun |
spellingShingle |
Shujun Fan Boyi Yang Xueyuan Zhi Yanxun Wang Jian Wei Quanmei Zheng Guifan Sun Interactions of Methylenetetrahydrofolate Reductase C677T Polymorphism with Environmental Factors on Hypertension Susceptibility International Journal of Environmental Research and Public Health environmental factors hypertension interaction MTHFR C677T |
author_facet |
Shujun Fan Boyi Yang Xueyuan Zhi Yanxun Wang Jian Wei Quanmei Zheng Guifan Sun |
author_sort |
Shujun Fan |
title |
Interactions of Methylenetetrahydrofolate Reductase C677T Polymorphism with Environmental Factors on Hypertension Susceptibility |
title_short |
Interactions of Methylenetetrahydrofolate Reductase C677T Polymorphism with Environmental Factors on Hypertension Susceptibility |
title_full |
Interactions of Methylenetetrahydrofolate Reductase C677T Polymorphism with Environmental Factors on Hypertension Susceptibility |
title_fullStr |
Interactions of Methylenetetrahydrofolate Reductase C677T Polymorphism with Environmental Factors on Hypertension Susceptibility |
title_full_unstemmed |
Interactions of Methylenetetrahydrofolate Reductase C677T Polymorphism with Environmental Factors on Hypertension Susceptibility |
title_sort |
interactions of methylenetetrahydrofolate reductase c677t polymorphism with environmental factors on hypertension susceptibility |
publisher |
MDPI AG |
series |
International Journal of Environmental Research and Public Health |
issn |
1660-4601 |
publishDate |
2016-06-01 |
description |
Hypertension is considered to be the result of genes, environment, and their interactions. Among them age, sex, tobacco use, alcohol consumption, and being overweight/obesity are well documented environmental determinants, and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is nominated as a potential genetic candidate. However, the synergistic effect of the MTHFR C677T polymorphism with these environmental factors on the risk of hypertension has received little attention. The aim of this study was to explore the associations of the MTHFR C677T polymorphism, environmental factors, and their interactions with hypertension predisposition in a Northern Chinese Han population. A total of 708 participants were enrolled in the study. The genotypes of the MTHFR C677T were determined by a TaqMan assay. We found that participants of an older age, being overweight/obesity, with a smoking habit, drinking habit, or carrying the 677T allele were at an increased risk of hypertension. Additionally, there existed marginally significant interactions of the polymorphism with age and overweight/obesity. However, future large, well-designed studies in Chinese and other populations, as well as mechanistic studies, are still needed to validate our findings, especially considering that the interactions observed in our study were only marginally significant. |
topic |
environmental factors hypertension interaction MTHFR C677T |
url |
http://www.mdpi.com/1660-4601/13/6/601 |
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