Infection-derived lipids elicit an immune deficiency circuit in arthropods
The insect IMD signalling pathway detects invading pathogens. Here the authors show that ticks have an alternative IMD system that lacks peptidoglycan receptors, IMD and FADD, and is instead reliant on interaction of the E3 ligase XIAP with the E2 conjugating enzyme Bendless.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2017-02-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14401 |
| id |
doaj-e93ff65b05c44e12b7a08eacf7918704 |
|---|---|
| record_format |
Article |
| spelling |
doaj-e93ff65b05c44e12b7a08eacf79187042021-05-11T07:47:01ZengNature Publishing GroupNature Communications2041-17232017-02-018111310.1038/ncomms14401Infection-derived lipids elicit an immune deficiency circuit in arthropodsDana K. Shaw0Xiaowei Wang1Lindsey J. Brown2Adela S. Oliva Chávez3Kathryn E. Reif4Alexis A. Smith5Alison J. Scott6Erin E. McClure7Vishant M. Boradia8Holly L. Hammond9Eric J. Sundberg10Greg A. Snyder11Lei Liu12Kathleen DePonte13Margarita Villar14Massaro W. Ueti15José de la Fuente16Robert K. Ernst17Utpal Pal18Erol Fikrig19Joao H. F. Pedra20Department of Microbiology and Immunology, University of Maryland School of MedicineDepartment of Microbiology and Immunology, University of Maryland School of MedicineDepartment of Microbiology and Immunology, University of Maryland School of MedicineDepartment of Microbiology and Immunology, University of Maryland School of MedicineUnited States Department of Agriculture, Animal Disease Research Unit, Agriculture Research ServiceDepartment of Veterinary Medicine, Virginia-Maryland Regional College of Veterinary Medicine, University of MarylandDepartment of Microbial Pathogenesis, University of Maryland School of DentistryDepartment of Microbiology and Immunology, University of Maryland School of MedicineDepartment of Microbiology and Immunology, University of Maryland School of MedicineDepartment of Microbiology and Immunology, University of Maryland School of MedicineDepartments of Medicine and Microbiology and Immunology, Institute of Human Virology, University of Maryland School of MedicineDepartments of Medicine and Microbiology and Immunology, Institute of Human Virology, University of Maryland School of MedicineDepartment of Internal Medicine, Section of Infectious Diseases, Yale University School of MedicineDepartment of Internal Medicine, Section of Infectious Diseases, Yale University School of MedicineSaBio. Instituto de Investigación en Recursos Cinegéticos IREC, CSIC-UCLM-JCCMUnited States Department of Agriculture, Animal Disease Research Unit, Agriculture Research ServiceSaBio. Instituto de Investigación en Recursos Cinegéticos IREC, CSIC-UCLM-JCCMDepartment of Microbiology and Immunology, University of Maryland School of MedicineDepartment of Veterinary Medicine, Virginia-Maryland Regional College of Veterinary Medicine, University of MarylandDepartment of Internal Medicine, Section of Infectious Diseases, Yale University School of MedicineDepartment of Microbiology and Immunology, University of Maryland School of MedicineThe insect IMD signalling pathway detects invading pathogens. Here the authors show that ticks have an alternative IMD system that lacks peptidoglycan receptors, IMD and FADD, and is instead reliant on interaction of the E3 ligase XIAP with the E2 conjugating enzyme Bendless.https://doi.org/10.1038/ncomms14401 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Dana K. Shaw Xiaowei Wang Lindsey J. Brown Adela S. Oliva Chávez Kathryn E. Reif Alexis A. Smith Alison J. Scott Erin E. McClure Vishant M. Boradia Holly L. Hammond Eric J. Sundberg Greg A. Snyder Lei Liu Kathleen DePonte Margarita Villar Massaro W. Ueti José de la Fuente Robert K. Ernst Utpal Pal Erol Fikrig Joao H. F. Pedra |
| spellingShingle |
Dana K. Shaw Xiaowei Wang Lindsey J. Brown Adela S. Oliva Chávez Kathryn E. Reif Alexis A. Smith Alison J. Scott Erin E. McClure Vishant M. Boradia Holly L. Hammond Eric J. Sundberg Greg A. Snyder Lei Liu Kathleen DePonte Margarita Villar Massaro W. Ueti José de la Fuente Robert K. Ernst Utpal Pal Erol Fikrig Joao H. F. Pedra Infection-derived lipids elicit an immune deficiency circuit in arthropods Nature Communications |
| author_facet |
Dana K. Shaw Xiaowei Wang Lindsey J. Brown Adela S. Oliva Chávez Kathryn E. Reif Alexis A. Smith Alison J. Scott Erin E. McClure Vishant M. Boradia Holly L. Hammond Eric J. Sundberg Greg A. Snyder Lei Liu Kathleen DePonte Margarita Villar Massaro W. Ueti José de la Fuente Robert K. Ernst Utpal Pal Erol Fikrig Joao H. F. Pedra |
| author_sort |
Dana K. Shaw |
| title |
Infection-derived lipids elicit an immune deficiency circuit in arthropods |
| title_short |
Infection-derived lipids elicit an immune deficiency circuit in arthropods |
| title_full |
Infection-derived lipids elicit an immune deficiency circuit in arthropods |
| title_fullStr |
Infection-derived lipids elicit an immune deficiency circuit in arthropods |
| title_full_unstemmed |
Infection-derived lipids elicit an immune deficiency circuit in arthropods |
| title_sort |
infection-derived lipids elicit an immune deficiency circuit in arthropods |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-02-01 |
| description |
The insect IMD signalling pathway detects invading pathogens. Here the authors show that ticks have an alternative IMD system that lacks peptidoglycan receptors, IMD and FADD, and is instead reliant on interaction of the E3 ligase XIAP with the E2 conjugating enzyme Bendless. |
| url |
https://doi.org/10.1038/ncomms14401 |
| work_keys_str_mv |
AT danakshaw infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT xiaoweiwang infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT lindseyjbrown infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT adelasolivachavez infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT kathrynereif infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT alexisasmith infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT alisonjscott infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT erinemcclure infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT vishantmboradia infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT hollylhammond infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT ericjsundberg infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT gregasnyder infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT leiliu infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT kathleendeponte infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT margaritavillar infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT massarowueti infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT josedelafuente infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT robertkernst infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT utpalpal infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT erolfikrig infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods AT joaohfpedra infectionderivedlipidselicitanimmunedeficiencycircuitinarthropods |
| _version_ |
1721451702699163648 |