TUMOR NECROSIS AND TRANSFORMING GROWTH FACTORS LEVEL IN SUB-CLINICAL STAGE OF CHRONIC HEPATITIS C
Abstract. Participation of pro- and anti-inflammatory cytokines in pathogenesis of inflammation and fibrosis served as a basis for studying TNFα and TGFβ levels in blood serum from the patients with chronic hepatitis C (CHC), as compared with modes and degree of patho-morphological changes in liver...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
SPb RAACI
2014-07-01
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| Series: | Medicinskaâ Immunologiâ |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/226 |
| Summary: | Abstract. Participation of pro- and anti-inflammatory cytokines in pathogenesis of inflammation and fibrosis served as a basis for studying TNFα and TGFβ levels in blood serum from the patients with chronic hepatitis C (CHC), as compared with modes and degree of patho-morphological changes in liver biopsies. We have detected a sufficient increase in serum TGFβ levels from patients in sub-clinical stage of CHC, independent on activity of the inflammatory process and expression of fibrosis, with a trend for its higher levels in cases of clinical decompensation at cirrhotic stage of the disease. Ambiguous changes of TNFα indexes in CHC patients with a tendency of higher levels in cases of higher histological activity and fibrosis of liver tissue allow us to consider a possible correlation with varying degree of compensatory and adaptive reactions. |
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| ISSN: | 1563-0625 2313-741X |