Atrial fibrillation burden, episode duration and frequency in relation to quality of life in patients with implantable cardiac monitor
Aims: To assess the relation between atrial fibrillation (AF) characteristics and health-related quality of life (QoL), and which AF characteristic had the greatest impact. Method: The AF characteristics burden (percentage of time in AF), duration and number of AF episodes/month were obtained from i...
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doaj-e944ced8fe1f4424b9354388ac68f4652021-06-29T04:12:57ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672021-06-0134100791Atrial fibrillation burden, episode duration and frequency in relation to quality of life in patients with implantable cardiac monitorVictoria Jansson0Lennart Bergfeldt1Jonas Schwieler2Göran Kennebäck3Aigars Rubulis4Steen M. Jensen5Pekka Raatikainen6Elena Sciaraffia7Carina Blomström-Lundqvist8Department of Medical Sciences, Uppsala University, Uppsala SE 751 85, Sweden; Corresponding author.Department of Molecular and Clinical Medicine/Cardiology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, and Region Västra Götaland, Department of Cardiology, Sahlgrenska University Hospital, Gothenburg SE 413 45, SwedenDepartment of Cardiology, Karolinska University Hospital, Solna SE 171 76, Stockholm, SwedenDepartment of Cardiology, Karolinska University Hospital, Solna SE 171 76, Stockholm, SwedenDepartment of Molecular and Clinical Medicine/Cardiology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, and Region Västra Götaland, Department of Cardiology, Sahlgrenska University Hospital, Gothenburg SE 413 45, SwedenHeart Centre and Department of Public Health and Clinical Medicine, Umeå University, Umeå SE 901 87, SwedenDepartment of Cardiology, Heart and Lung Center, Helsinki University Hospital, FinlandDepartment of Medical Sciences, Uppsala University, Uppsala SE 751 85, SwedenDepartment of Medical Sciences, Uppsala University, Uppsala SE 751 85, SwedenAims: To assess the relation between atrial fibrillation (AF) characteristics and health-related quality of life (QoL), and which AF characteristic had the greatest impact. Method: The AF characteristics burden (percentage of time in AF), duration and number of AF episodes/month were obtained from implantable cardiac monitors during the 2-month run-in period in 150 patients included in the randomized CAPTAF trial comparing early ablation and antiarrhythmic drug therapy. The QoL was measured by the General Health and Vitality dimensions of the 36-Item Short-Form Health Survey. AF characteristics were analysed continuously and in quartiles (Q1-Q4). Results: Greater AF burden (p = 0.003) and longer AF episodes (p = 0.013) were associated with impaired QoL (Vitality score only) in simple linear regression analyses. Greater AF burden was, however, the only AF characteristic associated with lower QoL, when adjusted for sex, type of AF, hypertension, heart rate above 110 beats per minute during AF, and beta-blocker use in multiple linear regression analyses. For every 10% increase in AF burden there was a 1.34-point decrease of Vitality score (95% confidence interval (CI) −2.67 to −0.02, p = 0.047). The Vitality score was 12 points lower (95% CI −22.73 to −1.27, p = 0.03) in patients with an AF burden > 33% (Q4) versus those with < 0.45% (Q1), but only in unadjusted analysis. Conclusion: AF burden had a greater impact on QoL (Vitality), than the duration and number of AF episodes, corroborating that AF burden may be the preferred outcome measure of rhythm control in trials including relatively healthy AF populations.http://www.sciencedirect.com/science/article/pii/S2352906721000798Atrial fibrillationHealth-related quality of lifeLoop recorderImplantable cardiac monitorAtrial fibrillation burdenRandomized |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Victoria Jansson Lennart Bergfeldt Jonas Schwieler Göran Kennebäck Aigars Rubulis Steen M. Jensen Pekka Raatikainen Elena Sciaraffia Carina Blomström-Lundqvist |
spellingShingle |
Victoria Jansson Lennart Bergfeldt Jonas Schwieler Göran Kennebäck Aigars Rubulis Steen M. Jensen Pekka Raatikainen Elena Sciaraffia Carina Blomström-Lundqvist Atrial fibrillation burden, episode duration and frequency in relation to quality of life in patients with implantable cardiac monitor International Journal of Cardiology: Heart & Vasculature Atrial fibrillation Health-related quality of life Loop recorder Implantable cardiac monitor Atrial fibrillation burden Randomized |
author_facet |
Victoria Jansson Lennart Bergfeldt Jonas Schwieler Göran Kennebäck Aigars Rubulis Steen M. Jensen Pekka Raatikainen Elena Sciaraffia Carina Blomström-Lundqvist |
author_sort |
Victoria Jansson |
title |
Atrial fibrillation burden, episode duration and frequency in relation to quality of life in patients with implantable cardiac monitor |
title_short |
Atrial fibrillation burden, episode duration and frequency in relation to quality of life in patients with implantable cardiac monitor |
title_full |
Atrial fibrillation burden, episode duration and frequency in relation to quality of life in patients with implantable cardiac monitor |
title_fullStr |
Atrial fibrillation burden, episode duration and frequency in relation to quality of life in patients with implantable cardiac monitor |
title_full_unstemmed |
Atrial fibrillation burden, episode duration and frequency in relation to quality of life in patients with implantable cardiac monitor |
title_sort |
atrial fibrillation burden, episode duration and frequency in relation to quality of life in patients with implantable cardiac monitor |
publisher |
Elsevier |
series |
International Journal of Cardiology: Heart & Vasculature |
issn |
2352-9067 |
publishDate |
2021-06-01 |
description |
Aims: To assess the relation between atrial fibrillation (AF) characteristics and health-related quality of life (QoL), and which AF characteristic had the greatest impact. Method: The AF characteristics burden (percentage of time in AF), duration and number of AF episodes/month were obtained from implantable cardiac monitors during the 2-month run-in period in 150 patients included in the randomized CAPTAF trial comparing early ablation and antiarrhythmic drug therapy. The QoL was measured by the General Health and Vitality dimensions of the 36-Item Short-Form Health Survey. AF characteristics were analysed continuously and in quartiles (Q1-Q4). Results: Greater AF burden (p = 0.003) and longer AF episodes (p = 0.013) were associated with impaired QoL (Vitality score only) in simple linear regression analyses. Greater AF burden was, however, the only AF characteristic associated with lower QoL, when adjusted for sex, type of AF, hypertension, heart rate above 110 beats per minute during AF, and beta-blocker use in multiple linear regression analyses. For every 10% increase in AF burden there was a 1.34-point decrease of Vitality score (95% confidence interval (CI) −2.67 to −0.02, p = 0.047). The Vitality score was 12 points lower (95% CI −22.73 to −1.27, p = 0.03) in patients with an AF burden > 33% (Q4) versus those with < 0.45% (Q1), but only in unadjusted analysis. Conclusion: AF burden had a greater impact on QoL (Vitality), than the duration and number of AF episodes, corroborating that AF burden may be the preferred outcome measure of rhythm control in trials including relatively healthy AF populations. |
topic |
Atrial fibrillation Health-related quality of life Loop recorder Implantable cardiac monitor Atrial fibrillation burden Randomized |
url |
http://www.sciencedirect.com/science/article/pii/S2352906721000798 |
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