PHILADELPHIA CHROMOSOME
Philadelphia (Ph’) chromosome is an abnormally short chromosome 22 formed as a result of translocation between chromosome 9 and 22. As a result the ABL gene from chromosome 9 joins the BCR gene on chromosome 22. This changed chromosome 22 with BCR-ABL fusion gene is called Ph’ chromosome. Philadel...
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Gomal Medical College, D.I.Khan, Pakistan
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doaj-e95ddad6bb054d1090554c4ae9d48c8d2020-11-25T01:43:46ZengGomal Medical College, D.I.Khan, PakistanGomal Journal of Medical Sciences1819-79731997-20672017-08-01151925PHILADELPHIA CHROMOSOMEHabibullah Khan0Department of Medicine, Gomal Medical College, D.I.KhanPhiladelphia (Ph’) chromosome is an abnormally short chromosome 22 formed as a result of translocation between chromosome 9 and 22. As a result the ABL gene from chromosome 9 joins the BCR gene on chromosome 22. This changed chromosome 22 with BCR-ABL fusion gene is called Ph’ chromosome. Philadelphia chromosome is found in most patients with chronic myelogenous leukemia (CML) and sometimes also in acute lymphoblastic leukemia and acute myelogenous leukemia. Its role in the development of CML is confirmed, and a therapy (Imatinib) directed against the gene product (Tyrosine kinase) has revolutionized the treatment of CML. Philadelphia chromosome was first identified in 1959 by David A. Hungerford and Peter Nowell in the city of Philadelphia. Later in 1973, Janet D. Rowley at University of Chicago identified the mechanism by which Ph’ chromosome is formed.http://gjms.com.pk/ojs24/index.php/gjms/article/view/1692philadelphia chromosomechronic myelogenous leukemia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Habibullah Khan |
spellingShingle |
Habibullah Khan PHILADELPHIA CHROMOSOME Gomal Journal of Medical Sciences philadelphia chromosome chronic myelogenous leukemia |
author_facet |
Habibullah Khan |
author_sort |
Habibullah Khan |
title |
PHILADELPHIA CHROMOSOME |
title_short |
PHILADELPHIA CHROMOSOME |
title_full |
PHILADELPHIA CHROMOSOME |
title_fullStr |
PHILADELPHIA CHROMOSOME |
title_full_unstemmed |
PHILADELPHIA CHROMOSOME |
title_sort |
philadelphia chromosome |
publisher |
Gomal Medical College, D.I.Khan, Pakistan |
series |
Gomal Journal of Medical Sciences |
issn |
1819-7973 1997-2067 |
publishDate |
2017-08-01 |
description |
Philadelphia (Ph’) chromosome is an abnormally short chromosome 22 formed as a result of translocation
between chromosome 9 and 22. As a result the ABL gene from chromosome 9 joins the BCR gene on chromosome
22. This changed chromosome 22 with BCR-ABL fusion gene is called Ph’ chromosome. Philadelphia
chromosome is found in most patients with chronic myelogenous leukemia (CML) and sometimes also in acute
lymphoblastic leukemia and acute myelogenous leukemia. Its role in the development of CML is confirmed, and
a therapy (Imatinib) directed against the gene product (Tyrosine kinase) has revolutionized the treatment of CML.
Philadelphia chromosome was first identified in 1959 by David A. Hungerford and Peter Nowell in the city
of Philadelphia. Later in 1973, Janet D. Rowley at University of Chicago identified the mechanism by which Ph’
chromosome is formed. |
topic |
philadelphia chromosome chronic myelogenous leukemia |
url |
http://gjms.com.pk/ojs24/index.php/gjms/article/view/1692 |
work_keys_str_mv |
AT habibullahkhan philadelphiachromosome |
_version_ |
1725031749049647104 |