Antibody Subclass Repertoire and Graft Outcome following Solid Organ Transplantation

Antibody Subclass Repertoire and Graft Outcome following Solid Organ Transplantation

Long-term outcomes in solid organ transplantation are constrained by the development of donor specific alloantibodies (DSA) against human leukocyte antigen (HLA) and other targets, which elicit antibody-mediated rejection (ABMR). However, antibody-mediated graft injury represents a broad continuum,...

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Bibliographic Details
Main Authors: Nicole M Valenzuela, Michelle J Hickey, Elaine F Reed
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Immunology
Subjects:
Transplantation Immunology
IgG subclasses
HLA antibodies
Isotype switching
Antibody-mediated Rejection
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00433/full

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