Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH

Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH

Polypeptide polymers can adopt natural protein secondary structures such as α-helices or β-sheets, and this unique feature is at the origin of some intriguing physico–chemical properties. In this work, we present how side chain imidazoylation of a poly(l-lysine) scaffold affords the preparation of p...

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Main Authors: Estefania Piedra-Arroni, Fatma Makni, Laura Severac, Jean-Luc Stigliani, Geneviève Pratviel, Colin Bonduelle
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:Polymers
Subjects:
smart polypeptides
imidazole-containing polymers
helix-to-coil transition
poly(lysine)
pH-responsive
Online Access:https://www.mdpi.com/2073-4360/9/7/276
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spelling doaj-e967cdd20c08450a89dd78b2068204192020-11-25T00:56:22ZengMDPI AGPolymers2073-43602017-07-019727610.3390/polym9070276polym9070276Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pHEstefania Piedra-Arroni0Fatma Makni1Laura Severac2Jean-Luc Stigliani3Geneviève Pratviel4Colin Bonduelle5CNRS, LCC (Laboratoire de Chimie de Coordination (UPR8241)), 205 route de Narbonne, F-31077 Toulouse 31400, FranceCNRS, LCC (Laboratoire de Chimie de Coordination (UPR8241)), 205 route de Narbonne, F-31077 Toulouse 31400, FranceCNRS, LCC (Laboratoire de Chimie de Coordination (UPR8241)), 205 route de Narbonne, F-31077 Toulouse 31400, FranceCNRS, LCC (Laboratoire de Chimie de Coordination (UPR8241)), 205 route de Narbonne, F-31077 Toulouse 31400, FranceCNRS, LCC (Laboratoire de Chimie de Coordination (UPR8241)), 205 route de Narbonne, F-31077 Toulouse 31400, FranceCNRS, LCC (Laboratoire de Chimie de Coordination (UPR8241)), 205 route de Narbonne, F-31077 Toulouse 31400, FrancePolypeptide polymers can adopt natural protein secondary structures such as α-helices or β-sheets, and this unique feature is at the origin of some intriguing physico–chemical properties. In this work, we present how side chain imidazoylation of a poly(l-lysine) scaffold affords the preparation of poly(histidine) counterparts exhibiting α-helix conformation. This structuring behavior is reversible and can be controlled by means of pH and or temperature changes.https://www.mdpi.com/2073-4360/9/7/276smart polypeptidesimidazole-containing polymershelix-to-coil transitionpoly(lysine)pH-responsive
collection DOAJ
language English
format Article
sources DOAJ
author Estefania Piedra-Arroni
Fatma Makni
Laura Severac
Jean-Luc Stigliani
Geneviève Pratviel
Colin Bonduelle
spellingShingle Estefania Piedra-Arroni
Fatma Makni
Laura Severac
Jean-Luc Stigliani
Geneviève Pratviel
Colin Bonduelle
Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH
Polymers
smart polypeptides
imidazole-containing polymers
helix-to-coil transition
poly(lysine)
pH-responsive
author_facet Estefania Piedra-Arroni
Fatma Makni
Laura Severac
Jean-Luc Stigliani
Geneviève Pratviel
Colin Bonduelle
author_sort Estefania Piedra-Arroni
title Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH
title_short Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH
title_full Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH
title_fullStr Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH
title_full_unstemmed Smart Poly(imidazoyl-l-lysine): Synthesis and Reversible Helix-to-Coil Transition at Neutral pH
title_sort smart poly(imidazoyl-l-lysine): synthesis and reversible helix-to-coil transition at neutral ph
publisher MDPI AG
series Polymers
issn 2073-4360
publishDate 2017-07-01
description Polypeptide polymers can adopt natural protein secondary structures such as α-helices or β-sheets, and this unique feature is at the origin of some intriguing physico–chemical properties. In this work, we present how side chain imidazoylation of a poly(l-lysine) scaffold affords the preparation of poly(histidine) counterparts exhibiting α-helix conformation. This structuring behavior is reversible and can be controlled by means of pH and or temperature changes.
topic smart polypeptides
imidazole-containing polymers
helix-to-coil transition
poly(lysine)
pH-responsive
url https://www.mdpi.com/2073-4360/9/7/276
work_keys_str_mv AT estefaniapiedraarroni smartpolyimidazoylllysinesynthesisandreversiblehelixtocoiltransitionatneutralph
AT fatmamakni smartpolyimidazoylllysinesynthesisandreversiblehelixtocoiltransitionatneutralph
AT lauraseverac smartpolyimidazoylllysinesynthesisandreversiblehelixtocoiltransitionatneutralph
AT jeanlucstigliani smartpolyimidazoylllysinesynthesisandreversiblehelixtocoiltransitionatneutralph
AT genevievepratviel smartpolyimidazoylllysinesynthesisandreversiblehelixtocoiltransitionatneutralph
AT colinbonduelle smartpolyimidazoylllysinesynthesisandreversiblehelixtocoiltransitionatneutralph
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