Blocking Type I Interferon Signaling Rescues Lymphocytes from Oxidative Stress, Exhaustion, and Apoptosis in a Streptozotocin-Induced Mouse Model of Type I Diabetes
Elevated levels of type I interferon (IFN) during type 1 diabetes mellitus (T1D) are associated with a defective immune response. In the present study, we investigated whether blocking type I IFN signaling during streptozotocin- (STZ-) induced T1D in mice improves lymphocyte proliferation and escape...
Main Authors: | Hany M. Ibrahim, Ibrahim A. El-Elaimy, Heba M. Saad Eldien, Badr Mohamed Badr, Danny M. Rabah, Gamal Badr |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2013-01-01
|
Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2013/148725 |
Similar Items
-
Increased Levels of Type 1 Interferon in a Type 1 Diabetic Mouse Model Induce the Elimination of B Cells from the Periphery by Apoptosis and Increase their Retention in the Spleen
by: Badr Mohamed Badr, et al.
Published: (2015-01-01) -
Thymoquinone Rescues T Lymphocytes from Gamma Irradiation-Induced Apoptosis and Exhaustion by Modulating Pro-Inflammatory Cytokine Levels and PD-1, Bax, and Bcl-2 Signaling
by: Mona Samy Guida, et al.
Published: (2016-02-01) -
Treatment of diabetic mice with undenatured whey protein accelerates the wound healing process by enhancing the expression of MIP-1α, MIP-2, KC, CX3CL1 and TGF-β in wounded tissue
by: Badr Gamal, et al.
Published: (2012-06-01) -
Sehgal Type Contractions on <i>b</i>-Metric Space
by: Badr Alqahtani, et al.
Published: (2018-11-01) -
Serum netrin and VCAM-1 as biomarker for Egyptian patients with type IΙ diabetes mellitus
by: Maher M. Fadel, et al.
Published: (2021-09-01)