Genetic Dissection of Alzheimer’s Disease Using <i>Drosophila</i> Models

Genetic Dissection of Alzheimer’s Disease Using <i>Drosophila</i> Models

Alzheimer&#8217;s disease (AD), a main cause of dementia, is the most common neurodegenerative disease that is related to abnormal accumulation of the amyloid &#946; (A&#946;) protein. Despite decades of intensive research, the mechanisms underlying AD remain elusive, and the only availa...

Full description

Bibliographic Details
Main Authors: Youngjae Jeon, Jae Ha Lee, Byoungyun Choi, So-Yoon Won, Kyoung Sang Cho
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
ad model
alzheimer’s disease
amyloid β
<i>drosophila</i>
functional genomics
Online Access:https://www.mdpi.com/1422-0067/21/3/884
id doaj-e986e3e516504225a8e4ab5f64f864ee
record_format Article
spelling doaj-e986e3e516504225a8e4ab5f64f864ee2020-11-25T02:06:05ZengMDPI AGInternational Journal of Molecular Sciences1422-00672020-01-0121388410.3390/ijms21030884ijms21030884Genetic Dissection of Alzheimer’s Disease Using <i>Drosophila</i> ModelsYoungjae Jeon0Jae Ha Lee1Byoungyun Choi2So-Yoon Won3Kyoung Sang Cho4Department of Biological Sciences, Konkuk University, Seoul 05029, KoreaDepartment of Biological Sciences, Konkuk University, Seoul 05029, KoreaDepartment of Biological Sciences, Konkuk University, Seoul 05029, KoreaDepartment of Biochemistry, Chungbuk National University College of Medicine, Cheongju 28644, KoreaDepartment of Biological Sciences, Konkuk University, Seoul 05029, KoreaAlzheimer&#8217;s disease (AD), a main cause of dementia, is the most common neurodegenerative disease that is related to abnormal accumulation of the amyloid &#946; (A&#946;) protein. Despite decades of intensive research, the mechanisms underlying AD remain elusive, and the only available treatment remains symptomatic. Molecular understanding of the pathogenesis and progression of AD is necessary to develop disease-modifying treatment. <i>Drosophila</i>, as the most advanced genetic model, has been used to explore the molecular mechanisms of AD in the last few decades. Here, we introduce <i>Drosophila</i> AD models based on human A&#946; and summarize the results of their genetic dissection. We also discuss the utility of functional genomics using the <i>Drosophila</i> system in the search for AD-associated molecular mechanisms in the post-genomic era.https://www.mdpi.com/1422-0067/21/3/884ad modelalzheimer’s diseaseamyloid β<i>drosophila</i>functional genomics
collection DOAJ
language English
format Article
sources DOAJ
author Youngjae Jeon
Jae Ha Lee
Byoungyun Choi
So-Yoon Won
Kyoung Sang Cho
spellingShingle Youngjae Jeon
Jae Ha Lee
Byoungyun Choi
So-Yoon Won
Kyoung Sang Cho
Genetic Dissection of Alzheimer’s Disease Using <i>Drosophila</i> Models
International Journal of Molecular Sciences
ad model
alzheimer’s disease
amyloid β
<i>drosophila</i>
functional genomics
author_facet Youngjae Jeon
Jae Ha Lee
Byoungyun Choi
So-Yoon Won
Kyoung Sang Cho
author_sort Youngjae Jeon
title Genetic Dissection of Alzheimer’s Disease Using <i>Drosophila</i> Models
title_short Genetic Dissection of Alzheimer’s Disease Using <i>Drosophila</i> Models
title_full Genetic Dissection of Alzheimer’s Disease Using <i>Drosophila</i> Models
title_fullStr Genetic Dissection of Alzheimer’s Disease Using <i>Drosophila</i> Models
title_full_unstemmed Genetic Dissection of Alzheimer’s Disease Using <i>Drosophila</i> Models
title_sort genetic dissection of alzheimer’s disease using <i>drosophila</i> models
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2020-01-01
description Alzheimer&#8217;s disease (AD), a main cause of dementia, is the most common neurodegenerative disease that is related to abnormal accumulation of the amyloid &#946; (A&#946;) protein. Despite decades of intensive research, the mechanisms underlying AD remain elusive, and the only available treatment remains symptomatic. Molecular understanding of the pathogenesis and progression of AD is necessary to develop disease-modifying treatment. <i>Drosophila</i>, as the most advanced genetic model, has been used to explore the molecular mechanisms of AD in the last few decades. Here, we introduce <i>Drosophila</i> AD models based on human A&#946; and summarize the results of their genetic dissection. We also discuss the utility of functional genomics using the <i>Drosophila</i> system in the search for AD-associated molecular mechanisms in the post-genomic era.
topic ad model
alzheimer’s disease
amyloid β
<i>drosophila</i>
functional genomics
url https://www.mdpi.com/1422-0067/21/3/884
work_keys_str_mv AT youngjaejeon geneticdissectionofalzheimersdiseaseusingidrosophilaimodels
AT jaehalee geneticdissectionofalzheimersdiseaseusingidrosophilaimodels
AT byoungyunchoi geneticdissectionofalzheimersdiseaseusingidrosophilaimodels
AT soyoonwon geneticdissectionofalzheimersdiseaseusingidrosophilaimodels
AT kyoungsangcho geneticdissectionofalzheimersdiseaseusingidrosophilaimodels
_version_ 1724935146139811840

Similar Items