Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria

Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria

Insertion sequences (IS) are common mobile genetic elements in bacteria, but their effects on bacterial evolution are not well understood. Here, Consuegra and colleagues investigate the dynamics and fitness consequences of IS elements in E. coli over 50,000 generations.

Bibliographic Details
Main Authors: Jessika Consuegra, Joël Gaffé, Richard E. Lenski, Thomas Hindré, Jeffrey E. Barrick, Olivier Tenaillon, Dominique Schneider
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21210-7
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spelling doaj-e996c6b3661a4328bd3da865b5d3e48a2021-02-14T12:12:08ZengNature Publishing GroupNature Communications2041-17232021-02-0112111210.1038/s41467-021-21210-7Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteriaJessika Consuegra0Joël Gaffé1Richard E. Lenski2Thomas Hindré3Jeffrey E. Barrick4Olivier Tenaillon5Dominique Schneider6Univ. Grenoble Alpes, CNRS, Grenoble INP, TIMC-IMAGUniv. Grenoble Alpes, CNRS, Grenoble INP, TIMC-IMAGDepartment of Microbiology and Molecular Genetics, Michigan State UniversityUniv. Grenoble Alpes, CNRS, Grenoble INP, TIMC-IMAGBEACON Center for the Study of Evolution in Action, Michigan State UniversityIAME, UMR 1137, INSERMUniv. Grenoble Alpes, CNRS, Grenoble INP, TIMC-IMAGInsertion sequences (IS) are common mobile genetic elements in bacteria, but their effects on bacterial evolution are not well understood. Here, Consuegra and colleagues investigate the dynamics and fitness consequences of IS elements in E. coli over 50,000 generations.https://doi.org/10.1038/s41467-021-21210-7
collection DOAJ
language English
format Article
sources DOAJ
author Jessika Consuegra
Joël Gaffé
Richard E. Lenski
Thomas Hindré
Jeffrey E. Barrick
Olivier Tenaillon
Dominique Schneider
spellingShingle Jessika Consuegra
Joël Gaffé
Richard E. Lenski
Thomas Hindré
Jeffrey E. Barrick
Olivier Tenaillon
Dominique Schneider
Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria
Nature Communications
author_facet Jessika Consuegra
Joël Gaffé
Richard E. Lenski
Thomas Hindré
Jeffrey E. Barrick
Olivier Tenaillon
Dominique Schneider
author_sort Jessika Consuegra
title Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria
title_short Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria
title_full Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria
title_fullStr Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria
title_full_unstemmed Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria
title_sort insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-02-01
description Insertion sequences (IS) are common mobile genetic elements in bacteria, but their effects on bacterial evolution are not well understood. Here, Consuegra and colleagues investigate the dynamics and fitness consequences of IS elements in E. coli over 50,000 generations.
url https://doi.org/10.1038/s41467-021-21210-7
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AT joelgaffe insertionsequencemediatedmutationsbothpromoteandconstrainevolvabilityduringalongtermexperimentwithbacteria
AT richardelenski insertionsequencemediatedmutationsbothpromoteandconstrainevolvabilityduringalongtermexperimentwithbacteria
AT thomashindre insertionsequencemediatedmutationsbothpromoteandconstrainevolvabilityduringalongtermexperimentwithbacteria
AT jeffreyebarrick insertionsequencemediatedmutationsbothpromoteandconstrainevolvabilityduringalongtermexperimentwithbacteria
AT oliviertenaillon insertionsequencemediatedmutationsbothpromoteandconstrainevolvabilityduringalongtermexperimentwithbacteria
AT dominiqueschneider insertionsequencemediatedmutationsbothpromoteandconstrainevolvabilityduringalongtermexperimentwithbacteria
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