Virus specific antibody - based remedies for the urgent prevention and treatment of Ebola virus disease

• Main Authors: T E Sizikova, V N Lebedev, S V Borisevich
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2019-11-01
• Series: Терапевтический архив
• Subjects: ebola virus; hemorrhagic fever; specific antibodies; convalescent’s plasma of blood; geterologic immunoglobulin; monoclonal antibodies; special prophylactic and current
• Online Access: https://ter-arkhiv.ru/0040-3660/article/viewFile/33717/pdf

The Ebola virus (member of Ebolavirus genus Filoviridae family) is the etiologic agent of extremely hazard human disease with high mortality rates (up to 90%). The most important components of spectrum of therapeutics for special prophylactic and current of disease, caused by Ebola virus, are prepares, based on virus specific antibodies (convalescent’s plasma, geterologic immunoglobulins, monoclonal antibodies. The use of different class therapeutics, based on virus specific antibodies, the possible improvements of its composition and strategy of its application for special prophylactic and current of disease, caused by Ebola virus, are considered in this review.