Realtime phase-amplitude coupling analysis of micro electrode recorded brain signals.

• Main Authors: David Chao-Chia Lu, Chadwick Boulay, Adrian D C Chan, Adam J Sachs
• Format: Article
• Language: English
• Published: Public Library of Science (PLoS) 2018-01-01
• Series: PLoS ONE
• Online Access: http://europepmc.org/articles/PMC6161890?pdf=render

OBJECTIVE:To demonstrate a method to calculate phase amplitude coupling (PAC) quickly and robustly for realtime applications. METHODS:We designed and implemented a multirate PAC algorithm with efficient filter bank processing and efficient computation of PAC for many frequency-pair combinations. We tested the developed algorithm for computing PAC on simulated data and on intraoperative neural recording data obtained during deep brain stimulation (DBS) electrode implantation surgery. RESULTS:A combination of parallelized frequency-domain filtering and modulation index for PAC estimation provided robust results that could be calculated in real time on modest computing hardware. CONCLUSION:The standard methods for calculating PAC can be optimized for quick and robust performance. SIGNIFICANCE:These results demonstrated that PAC can be extracted in real time and is suitable for neurofeedback applications.