Relationship between bone mineral density and fragility fracture risk: a case-control study in Changsha, China
Abstract Background Fragility fracture is associated with bone mineral density (BMD), and most databases used in related researches are instrument-matched. Little is known about the relationship between BMD and fragility fracture risk of native Chinese, especially using local databases as reference...
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2021-08-01
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Series: | BMC Musculoskeletal Disorders |
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Online Access: | https://doi.org/10.1186/s12891-021-04616-8 |
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Article |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hong-Li Li Yi Shen Li-Hua Tan Song-bo Fu Ru-Chun Dai Ling-Qing Yuan Zhi-Feng Sheng Zhong-Jian Xie Xian-Ping Wu Er-Yuan Liao Xu-Lei Tang Xi-Yu Wu |
spellingShingle |
Hong-Li Li Yi Shen Li-Hua Tan Song-bo Fu Ru-Chun Dai Ling-Qing Yuan Zhi-Feng Sheng Zhong-Jian Xie Xian-Ping Wu Er-Yuan Liao Xu-Lei Tang Xi-Yu Wu Relationship between bone mineral density and fragility fracture risk: a case-control study in Changsha, China BMC Musculoskeletal Disorders Fragility fracture Osteoporosis Bone mineral density T-score Fracture risk |
author_facet |
Hong-Li Li Yi Shen Li-Hua Tan Song-bo Fu Ru-Chun Dai Ling-Qing Yuan Zhi-Feng Sheng Zhong-Jian Xie Xian-Ping Wu Er-Yuan Liao Xu-Lei Tang Xi-Yu Wu |
author_sort |
Hong-Li Li |
title |
Relationship between bone mineral density and fragility fracture risk: a case-control study in Changsha, China |
title_short |
Relationship between bone mineral density and fragility fracture risk: a case-control study in Changsha, China |
title_full |
Relationship between bone mineral density and fragility fracture risk: a case-control study in Changsha, China |
title_fullStr |
Relationship between bone mineral density and fragility fracture risk: a case-control study in Changsha, China |
title_full_unstemmed |
Relationship between bone mineral density and fragility fracture risk: a case-control study in Changsha, China |
title_sort |
relationship between bone mineral density and fragility fracture risk: a case-control study in changsha, china |
publisher |
BMC |
series |
BMC Musculoskeletal Disorders |
issn |
1471-2474 |
publishDate |
2021-08-01 |
description |
Abstract Background Fragility fracture is associated with bone mineral density (BMD), and most databases used in related researches are instrument-matched. Little is known about the relationship between BMD and fragility fracture risk of native Chinese, especially using local databases as reference databases. Objective To investigate relationship between BMD and risk of fragility fracture in native China. Methods 3,324 cases, including 2,423 women (67.7 ± 8.9 years) and 901 men (68.4 ± 11.6 years) having radiological fragility fractures and 3,324 age- and gender-matched controls participated in the study. We measured BMD at posteroanterior spine and hip using dual-energy X-ray absorptiometry (DXA), calculated BMD measurement parameters based on our own BMD reference database. Results BMDs and mean T-scores were lower in case group (with clinical fragility) than in control group (without clinical fragility). In patients with fragility fractures, prevalence of lumbar osteoporosis, low bone mass, and normal BMD were 78.9 %, 19.3 %, and 1.8 %, respectively, in women, and 49.5, 44.8 %, and 5.7 %, respectively, in men. In hip, these prevalence rates were 67.2 %, 28.4 %, and 4.4 % in females, and 43.2 %, 45.9 %, and 10.9 % in males, respectively, showing differences between females and males. Multivariate Cox regression analysis showed that after adjusting age, height, weight, and body mass index, fracture hazard ratio (HR) increased by 2.7–2.8 times (95 % CI 2.5–3.1) and 3.6–4.1 times (95 %CI 3.0–5.1) for women and men respectively with decreasing BMD parameters. In both sexes, risk of fragility fracture increased approximately 1.6–1.7 times (95 % CI 1.5–1.8) for every 1 T-score reduction in BMD. Conclusions Risk of clinical fragility fracture increases with decreasing BMD measurement parameters and anthropometric indicators in native China, and fracture HR varies from gender and site. |
topic |
Fragility fracture Osteoporosis Bone mineral density T-score Fracture risk |
url |
https://doi.org/10.1186/s12891-021-04616-8 |
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doaj-e9ac3604be004fc8adff58215673ae322021-08-29T11:29:40ZengBMCBMC Musculoskeletal Disorders1471-24742021-08-012211810.1186/s12891-021-04616-8Relationship between bone mineral density and fragility fracture risk: a case-control study in Changsha, ChinaHong-Li Li0Yi Shen1Li-Hua Tan2Song-bo Fu3Ru-Chun Dai4Ling-Qing Yuan5Zhi-Feng Sheng6Zhong-Jian Xie7Xian-Ping Wu8Er-Yuan Liao9Xu-Lei Tang10Xi-Yu Wu11National Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, The Second Xiangya Hospital, Central South UniversityDepartment of Orthopaedics, The Second Xiangya Hospital, Central South UniversityDepartment of Radiology, The Second Xiangya Hospital, Central South UniversityDepartment of Endocrinology, The First Hospital of Lanzhou UniversityNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, The Second Xiangya Hospital, Central South UniversityNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, The Second Xiangya Hospital, Central South UniversityNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, The Second Xiangya Hospital, Central South UniversityNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, The Second Xiangya Hospital, Central South UniversityNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, The Second Xiangya Hospital, Central South UniversityNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, The Second Xiangya Hospital, Central South UniversityDepartment of Endocrinology, The First Hospital of Lanzhou UniversityNational Clinical Research Center for Metabolic Diseases, Department of Metabolism and Endocrinology, Hunan Provincial Key Laboratory for Metabolic Bone Diseases, The Second Xiangya Hospital, Central South UniversityAbstract Background Fragility fracture is associated with bone mineral density (BMD), and most databases used in related researches are instrument-matched. Little is known about the relationship between BMD and fragility fracture risk of native Chinese, especially using local databases as reference databases. Objective To investigate relationship between BMD and risk of fragility fracture in native China. Methods 3,324 cases, including 2,423 women (67.7 ± 8.9 years) and 901 men (68.4 ± 11.6 years) having radiological fragility fractures and 3,324 age- and gender-matched controls participated in the study. We measured BMD at posteroanterior spine and hip using dual-energy X-ray absorptiometry (DXA), calculated BMD measurement parameters based on our own BMD reference database. Results BMDs and mean T-scores were lower in case group (with clinical fragility) than in control group (without clinical fragility). In patients with fragility fractures, prevalence of lumbar osteoporosis, low bone mass, and normal BMD were 78.9 %, 19.3 %, and 1.8 %, respectively, in women, and 49.5, 44.8 %, and 5.7 %, respectively, in men. In hip, these prevalence rates were 67.2 %, 28.4 %, and 4.4 % in females, and 43.2 %, 45.9 %, and 10.9 % in males, respectively, showing differences between females and males. Multivariate Cox regression analysis showed that after adjusting age, height, weight, and body mass index, fracture hazard ratio (HR) increased by 2.7–2.8 times (95 % CI 2.5–3.1) and 3.6–4.1 times (95 %CI 3.0–5.1) for women and men respectively with decreasing BMD parameters. In both sexes, risk of fragility fracture increased approximately 1.6–1.7 times (95 % CI 1.5–1.8) for every 1 T-score reduction in BMD. Conclusions Risk of clinical fragility fracture increases with decreasing BMD measurement parameters and anthropometric indicators in native China, and fracture HR varies from gender and site.https://doi.org/10.1186/s12891-021-04616-8Fragility fractureOsteoporosisBone mineral densityT-scoreFracture risk |