Immune Response to COVID-19 During Pregnancy
Pregnant women are generally more susceptible to viral infection. Although the impact of SARS-CoV-2 on pregnant women remains to be determined, evidence indicates that risks of adverse clinical outcomes are similar in pregnancy to the general population. Here we analyzed clinical symptoms and outcom...
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doaj-e9ae1d9d3f1f4b11a056c65940a2cd8c2021-05-03T05:05:09ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-05-011210.3389/fimmu.2021.675476675476Immune Response to COVID-19 During PregnancyGe Chen0Qiuyue Liao1Jihui Ai2Bin Yang3Hualin Bai4Jing Chen5Fengyuan Liu6Yang Cao7Haiyi Liu8Kezhen Li9Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaBiological Sciences Greenhouse, College of Art & Sciences, The Ohio State University, Columbus, OH, United StatesDepartment of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaPregnant women are generally more susceptible to viral infection. Although the impact of SARS-CoV-2 on pregnant women remains to be determined, evidence indicates that risks of adverse clinical outcomes are similar in pregnancy to the general population. Here we analyzed clinical symptoms and outcomes of 20 pregnant and 299 reproductive-aged non-pregnant female COVID-19 patients who were hospitalized during the same period. Laboratory measurements were compared among mild cases and healthy pregnant women. Our study found that pregnant patients showed enhanced innate immune response evident by higher neutrophils and C-reactive protein. Cytokines, chemokines, and growth factors (CCGFs) profiles from 11 pregnant and 4 non-pregnant COVID-19 patients and 10 healthy pregnant female patients, and lymphocyte subsets analysis of 7 pregnant patients and 19 non-pregnant patients, indicate suppressed cytokine storm and potential enhanced CD8+ T cell and NK cell activity in pregnant patients with COVID-19, which may be essential in contributing to the unique anti-SARS-CoV-2 response in pregnancy.https://www.frontiersin.org/articles/10.3389/fimmu.2021.675476/fullCOVID-19pregnant womenimmune responselymphocyte subtypescytokines |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ge Chen Qiuyue Liao Jihui Ai Bin Yang Hualin Bai Jing Chen Fengyuan Liu Yang Cao Haiyi Liu Kezhen Li |
spellingShingle |
Ge Chen Qiuyue Liao Jihui Ai Bin Yang Hualin Bai Jing Chen Fengyuan Liu Yang Cao Haiyi Liu Kezhen Li Immune Response to COVID-19 During Pregnancy Frontiers in Immunology COVID-19 pregnant women immune response lymphocyte subtypes cytokines |
author_facet |
Ge Chen Qiuyue Liao Jihui Ai Bin Yang Hualin Bai Jing Chen Fengyuan Liu Yang Cao Haiyi Liu Kezhen Li |
author_sort |
Ge Chen |
title |
Immune Response to COVID-19 During Pregnancy |
title_short |
Immune Response to COVID-19 During Pregnancy |
title_full |
Immune Response to COVID-19 During Pregnancy |
title_fullStr |
Immune Response to COVID-19 During Pregnancy |
title_full_unstemmed |
Immune Response to COVID-19 During Pregnancy |
title_sort |
immune response to covid-19 during pregnancy |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2021-05-01 |
description |
Pregnant women are generally more susceptible to viral infection. Although the impact of SARS-CoV-2 on pregnant women remains to be determined, evidence indicates that risks of adverse clinical outcomes are similar in pregnancy to the general population. Here we analyzed clinical symptoms and outcomes of 20 pregnant and 299 reproductive-aged non-pregnant female COVID-19 patients who were hospitalized during the same period. Laboratory measurements were compared among mild cases and healthy pregnant women. Our study found that pregnant patients showed enhanced innate immune response evident by higher neutrophils and C-reactive protein. Cytokines, chemokines, and growth factors (CCGFs) profiles from 11 pregnant and 4 non-pregnant COVID-19 patients and 10 healthy pregnant female patients, and lymphocyte subsets analysis of 7 pregnant patients and 19 non-pregnant patients, indicate suppressed cytokine storm and potential enhanced CD8+ T cell and NK cell activity in pregnant patients with COVID-19, which may be essential in contributing to the unique anti-SARS-CoV-2 response in pregnancy. |
topic |
COVID-19 pregnant women immune response lymphocyte subtypes cytokines |
url |
https://www.frontiersin.org/articles/10.3389/fimmu.2021.675476/full |
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