Occupational exposure to solvents and acute myeloid leukemia: a population-based, case–control study in four Nordic countries
OBJECTIVE: The aim of the current study was to assess the relation between occupational exposure to solvents and the risk of acute myeloid leukemia (AML). METHODS: Altogether, this study comprises 15 332 incident cases of AML diagnosed in Finland, Norway, Sweden and Iceland from 1961–2005 and 76 660...
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Nordic Association of Occupational Safety and Health (NOROSH)
2014-09-01
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doaj-e9c0cd759be14655b991e6192dafeb5a2021-04-22T08:32:13ZengNordic Association of Occupational Safety and Health (NOROSH)Scandinavian Journal of Work, Environment & Health0355-31401795-990X2014-09-0140551151710.5271/sjweh.34363436Occupational exposure to solvents and acute myeloid leukemia: a population-based, case–control study in four Nordic countriesMadar Talibov0Susanna Lehtinen-JacksJan Ivar MartinsenKristina KjærheimElsebeth LyngePär SparénLaufey TryggvadottirElisabete WeiderpassTimo KauppinenPentti KyyrönenEero PukkalaSchool of Health Sciences, University of Tampere, FI-33014, Tampere, Finland.OBJECTIVE: The aim of the current study was to assess the relation between occupational exposure to solvents and the risk of acute myeloid leukemia (AML). METHODS: Altogether, this study comprises 15 332 incident cases of AML diagnosed in Finland, Norway, Sweden and Iceland from 1961–2005 and 76 660 controls matched by year of birth, sex, and country. Occupational records were linked with Nordic Occupational Cancer Study job exposure matrix (JEM) to estimate quantitative values for 26 occupational exposure factors. Hazard ratios (HR) with 95% confidence intervals (95% CI) were estimated by using conditional logistic regression models. RESULTS: We did not observe statistically significantly increased risk for exposure to any of the solvents. HR estimates for high levels of toluene (HR 1.35, 95% CI 0.74–2.46), aromatic hydrocarbon solvents (ARHC) (HR 1.18, 95% CI 0.76–1.86), and moderate-to-high levels of trichloroethylene were slightly but non-significantly elevated. We did not observe an association between benzene exposure and AML in this study. CONCLUSIONS: This study did not provide clear evidence for an association between occupational solvent exposure and AML. There was some indication for an excess risk in the groups of workers exposed to toluene, trichloroethylene and ARHC. https://www.sjweh.fi/show_abstract.php?abstract_id=3436 toluenecase–control studyjob exposure matrixjemacute myeloid leukemianordic occupational cancer studyaromatic hydrocarbon solventoccupational exposuresolventbenzenecancertrichloroethyleneleukemia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Madar Talibov Susanna Lehtinen-Jacks Jan Ivar Martinsen Kristina Kjærheim Elsebeth Lynge Pär Sparén Laufey Tryggvadottir Elisabete Weiderpass Timo Kauppinen Pentti Kyyrönen Eero Pukkala |
spellingShingle |
Madar Talibov Susanna Lehtinen-Jacks Jan Ivar Martinsen Kristina Kjærheim Elsebeth Lynge Pär Sparén Laufey Tryggvadottir Elisabete Weiderpass Timo Kauppinen Pentti Kyyrönen Eero Pukkala Occupational exposure to solvents and acute myeloid leukemia: a population-based, case–control study in four Nordic countries Scandinavian Journal of Work, Environment & Health toluene case–control study job exposure matrix jem acute myeloid leukemia nordic occupational cancer study aromatic hydrocarbon solvent occupational exposure solvent benzene cancer trichloroethylene leukemia |
author_facet |
Madar Talibov Susanna Lehtinen-Jacks Jan Ivar Martinsen Kristina Kjærheim Elsebeth Lynge Pär Sparén Laufey Tryggvadottir Elisabete Weiderpass Timo Kauppinen Pentti Kyyrönen Eero Pukkala |
author_sort |
Madar Talibov |
title |
Occupational exposure to solvents and acute myeloid leukemia: a population-based, case–control study in four Nordic countries |
title_short |
Occupational exposure to solvents and acute myeloid leukemia: a population-based, case–control study in four Nordic countries |
title_full |
Occupational exposure to solvents and acute myeloid leukemia: a population-based, case–control study in four Nordic countries |
title_fullStr |
Occupational exposure to solvents and acute myeloid leukemia: a population-based, case–control study in four Nordic countries |
title_full_unstemmed |
Occupational exposure to solvents and acute myeloid leukemia: a population-based, case–control study in four Nordic countries |
title_sort |
occupational exposure to solvents and acute myeloid leukemia: a population-based, case–control study in four nordic countries |
publisher |
Nordic Association of Occupational Safety and Health (NOROSH) |
series |
Scandinavian Journal of Work, Environment & Health |
issn |
0355-3140 1795-990X |
publishDate |
2014-09-01 |
description |
OBJECTIVE: The aim of the current study was to assess the relation between occupational exposure to solvents and the risk of acute myeloid leukemia (AML). METHODS: Altogether, this study comprises 15 332 incident cases of AML diagnosed in Finland, Norway, Sweden and Iceland from 1961–2005 and 76 660 controls matched by year of birth, sex, and country. Occupational records were linked with Nordic Occupational Cancer Study job exposure matrix (JEM) to estimate quantitative values for 26 occupational exposure factors. Hazard ratios (HR) with 95% confidence intervals (95% CI) were estimated by using conditional logistic regression models. RESULTS: We did not observe statistically significantly increased risk for exposure to any of the solvents. HR estimates for high levels of toluene (HR 1.35, 95% CI 0.74–2.46), aromatic hydrocarbon solvents (ARHC) (HR 1.18, 95% CI 0.76–1.86), and moderate-to-high levels of trichloroethylene were slightly but non-significantly elevated. We did not observe an association between benzene exposure and AML in this study. CONCLUSIONS: This study did not provide clear evidence for an association between occupational solvent exposure and AML. There was some indication for an excess risk in the groups of workers exposed to toluene, trichloroethylene and ARHC. |
topic |
toluene case–control study job exposure matrix jem acute myeloid leukemia nordic occupational cancer study aromatic hydrocarbon solvent occupational exposure solvent benzene cancer trichloroethylene leukemia |
url |
https://www.sjweh.fi/show_abstract.php?abstract_id=3436
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