Antihypertensive Effect of Galegine from <i>Biebersteinia heterostemon</i> in Rats
The aerial part of <i>Biebersteinia heterostemon</i> Maxim. (Geraniaceae Biebersteiniaceae) known as <i>ming jian na bao</i> in Chinese, has been traditionally used in Tibetan folk medicine for treatment of diabetes and hypertension. The aim of the present study was to evalua...
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doaj-e9c36b94025c414b8211c8118e23846a2021-08-26T14:07:21ZengMDPI AGMolecules1420-30492021-08-01264830483010.3390/molecules26164830Antihypertensive Effect of Galegine from <i>Biebersteinia heterostemon</i> in RatsWeien Wang0Xiaofeng Zhang1School of Chemistry and Chemical Engineering, Qinghai Normal University, Xining 810008, ChinaNorthwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810007, ChinaThe aerial part of <i>Biebersteinia heterostemon</i> Maxim. (Geraniaceae Biebersteiniaceae) known as <i>ming jian na bao</i> in Chinese, has been traditionally used in Tibetan folk medicine for treatment of diabetes and hypertension. The aim of the present study was to evaluate the effects of galegine obtained from an ethanol extract of the entire <i>Biebersteinia heterostemon</i> plant on the rat’s cardiovascular system in order to characterize its contributions as an antihypertensive agent. The antihypertensive effect of galegine was investigated in pentobarbital-anesthetized hypertensive rats at three dose levels based on the LD<sub>50</sub> of galegine. Meanwhile a positive control group received dimaprit with the same procedure. Dimaprit infusion induced a significant hypotension which declined by an average margin of 20%. Simultaneously, single administration of galegine at the doses of 2.5, 5, and 10 mg/kg by intraperitoneal injection induced an immediate and dose-dependent decrease in mean arterial blood pressure (MABP) by an average margin of 40% with a rapid increase in heart rate (HR). We demonstrated that galegine is effective in reducing blood pressure in anesthetized hypertensive rats with rapid onset and a dose-related duration of the effects. The results indicate that galegine was the bioactive compound which can be used as a pharmacophore to design new hypertensive agents.https://www.mdpi.com/1420-3049/26/16/4830<i>Biebersteinia heterostemon</i>galeginehypotensivetoxicity |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Weien Wang Xiaofeng Zhang |
spellingShingle |
Weien Wang Xiaofeng Zhang Antihypertensive Effect of Galegine from <i>Biebersteinia heterostemon</i> in Rats Molecules <i>Biebersteinia heterostemon</i> galegine hypotensive toxicity |
author_facet |
Weien Wang Xiaofeng Zhang |
author_sort |
Weien Wang |
title |
Antihypertensive Effect of Galegine from <i>Biebersteinia heterostemon</i> in Rats |
title_short |
Antihypertensive Effect of Galegine from <i>Biebersteinia heterostemon</i> in Rats |
title_full |
Antihypertensive Effect of Galegine from <i>Biebersteinia heterostemon</i> in Rats |
title_fullStr |
Antihypertensive Effect of Galegine from <i>Biebersteinia heterostemon</i> in Rats |
title_full_unstemmed |
Antihypertensive Effect of Galegine from <i>Biebersteinia heterostemon</i> in Rats |
title_sort |
antihypertensive effect of galegine from <i>biebersteinia heterostemon</i> in rats |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2021-08-01 |
description |
The aerial part of <i>Biebersteinia heterostemon</i> Maxim. (Geraniaceae Biebersteiniaceae) known as <i>ming jian na bao</i> in Chinese, has been traditionally used in Tibetan folk medicine for treatment of diabetes and hypertension. The aim of the present study was to evaluate the effects of galegine obtained from an ethanol extract of the entire <i>Biebersteinia heterostemon</i> plant on the rat’s cardiovascular system in order to characterize its contributions as an antihypertensive agent. The antihypertensive effect of galegine was investigated in pentobarbital-anesthetized hypertensive rats at three dose levels based on the LD<sub>50</sub> of galegine. Meanwhile a positive control group received dimaprit with the same procedure. Dimaprit infusion induced a significant hypotension which declined by an average margin of 20%. Simultaneously, single administration of galegine at the doses of 2.5, 5, and 10 mg/kg by intraperitoneal injection induced an immediate and dose-dependent decrease in mean arterial blood pressure (MABP) by an average margin of 40% with a rapid increase in heart rate (HR). We demonstrated that galegine is effective in reducing blood pressure in anesthetized hypertensive rats with rapid onset and a dose-related duration of the effects. The results indicate that galegine was the bioactive compound which can be used as a pharmacophore to design new hypertensive agents. |
topic |
<i>Biebersteinia heterostemon</i> galegine hypotensive toxicity |
url |
https://www.mdpi.com/1420-3049/26/16/4830 |
work_keys_str_mv |
AT weienwang antihypertensiveeffectofgaleginefromibiebersteiniaheterostemoniinrats AT xiaofengzhang antihypertensiveeffectofgaleginefromibiebersteiniaheterostemoniinrats |
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1721191276352634880 |