Safety and efficacy of l‐tryptophan produced by fermentation with Escherichia coli KCCM 80135 for all animal species
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐tryptophan produced by fermentation using Escherichia coli KCCM 80135 when used as a nutritional additive in feed a...
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doaj-e9c3be871707496ba80da810d7a1f0bb2021-05-03T04:14:16ZengWileyEFSA Journal1831-47322019-05-01175n/an/a10.2903/j.efsa.2019.5694Safety and efficacy of l‐tryptophan produced by fermentation with Escherichia coli KCCM 80135 for all animal speciesEFSA Panel on Additives and Products or Substances used in Animal Feed (EFSA FEEDAP Panel)Vasileios BampidisMaria de LourdesBastosHenrik ChristensenBirgit DusemundMaryline KoubaMojca Kos DurjavaMarta López‐AlonsoSecundino López PuenteFrancesca MarconBaltasar MayoAlena PechováMariana PetkovaYolanda SanzRoberto Edoardo VillaRuud WoutersenLucio CostaNoël DierickGerhard FlachowskyBoet GlandorfLieve HermanLubomir LengAlberto MantovaniMaria SaarelaRobert John WallaceMontserrat AnguitaJordi Tarrés‐CallFernando RamosAbstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐tryptophan produced by fermentation using Escherichia coli KCCM 80135 when used as a nutritional additive in feed and water for drinking for all animal species. The production strain and its recombinant DNA were not detected in the additive. l‐Tryptophan produced by fermentation with E. coli KCCM 80135 does not raise any safety concern with regard to the genetic modification of the production strain. The use of l‐tryptophan produced using E. coli KCCM 80135 in supplementing feed to compensate for tryptophan deficiency in feedingstuffs is safe for non‐ruminant target species. Using unprotected forms of tryptophan in ruminants can be a risk. The use of l‐tryptophan produced by fermentation using E. coli KCCM 80135 in animal nutrition presents no safety concerns to consumers of animal products. l‐Tryptophan produced by E. coli KCCM 80135 is not toxic by inhalation. The additive is not an irritant to skin and eyes, and it is not a skin sensitiser. The additive under assessment is considered safe for the environment. It is regarded as an effective source of the amino acid l‐tryptophan for all non‐ruminant species. If the additive l‐tryptophan is intended for use in ruminants, it should be protected from ruminal degradation.https://doi.org/10.2903/j.efsa.2019.5694nutritional additiveamino acidsl‐tryptophansafetyefficacyEscherichia coli KCCM 80135 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
EFSA Panel on Additives and Products or Substances used in Animal Feed (EFSA FEEDAP Panel) Vasileios Bampidis Maria de LourdesBastos Henrik Christensen Birgit Dusemund Maryline Kouba Mojca Kos Durjava Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Lucio Costa Noël Dierick Gerhard Flachowsky Boet Glandorf Lieve Herman Lubomir Leng Alberto Mantovani Maria Saarela Robert John Wallace Montserrat Anguita Jordi Tarrés‐Call Fernando Ramos |
spellingShingle |
EFSA Panel on Additives and Products or Substances used in Animal Feed (EFSA FEEDAP Panel) Vasileios Bampidis Maria de LourdesBastos Henrik Christensen Birgit Dusemund Maryline Kouba Mojca Kos Durjava Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Lucio Costa Noël Dierick Gerhard Flachowsky Boet Glandorf Lieve Herman Lubomir Leng Alberto Mantovani Maria Saarela Robert John Wallace Montserrat Anguita Jordi Tarrés‐Call Fernando Ramos Safety and efficacy of l‐tryptophan produced by fermentation with Escherichia coli KCCM 80135 for all animal species EFSA Journal nutritional additive amino acids l‐tryptophan safety efficacy Escherichia coli KCCM 80135 |
author_facet |
EFSA Panel on Additives and Products or Substances used in Animal Feed (EFSA FEEDAP Panel) Vasileios Bampidis Maria de LourdesBastos Henrik Christensen Birgit Dusemund Maryline Kouba Mojca Kos Durjava Marta López‐Alonso Secundino López Puente Francesca Marcon Baltasar Mayo Alena Pechová Mariana Petkova Yolanda Sanz Roberto Edoardo Villa Ruud Woutersen Lucio Costa Noël Dierick Gerhard Flachowsky Boet Glandorf Lieve Herman Lubomir Leng Alberto Mantovani Maria Saarela Robert John Wallace Montserrat Anguita Jordi Tarrés‐Call Fernando Ramos |
author_sort |
EFSA Panel on Additives and Products or Substances used in Animal Feed (EFSA FEEDAP Panel) |
title |
Safety and efficacy of l‐tryptophan produced by fermentation with Escherichia coli KCCM 80135 for all animal species |
title_short |
Safety and efficacy of l‐tryptophan produced by fermentation with Escherichia coli KCCM 80135 for all animal species |
title_full |
Safety and efficacy of l‐tryptophan produced by fermentation with Escherichia coli KCCM 80135 for all animal species |
title_fullStr |
Safety and efficacy of l‐tryptophan produced by fermentation with Escherichia coli KCCM 80135 for all animal species |
title_full_unstemmed |
Safety and efficacy of l‐tryptophan produced by fermentation with Escherichia coli KCCM 80135 for all animal species |
title_sort |
safety and efficacy of l‐tryptophan produced by fermentation with escherichia coli kccm 80135 for all animal species |
publisher |
Wiley |
series |
EFSA Journal |
issn |
1831-4732 |
publishDate |
2019-05-01 |
description |
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐tryptophan produced by fermentation using Escherichia coli KCCM 80135 when used as a nutritional additive in feed and water for drinking for all animal species. The production strain and its recombinant DNA were not detected in the additive. l‐Tryptophan produced by fermentation with E. coli KCCM 80135 does not raise any safety concern with regard to the genetic modification of the production strain. The use of l‐tryptophan produced using E. coli KCCM 80135 in supplementing feed to compensate for tryptophan deficiency in feedingstuffs is safe for non‐ruminant target species. Using unprotected forms of tryptophan in ruminants can be a risk. The use of l‐tryptophan produced by fermentation using E. coli KCCM 80135 in animal nutrition presents no safety concerns to consumers of animal products. l‐Tryptophan produced by E. coli KCCM 80135 is not toxic by inhalation. The additive is not an irritant to skin and eyes, and it is not a skin sensitiser. The additive under assessment is considered safe for the environment. It is regarded as an effective source of the amino acid l‐tryptophan for all non‐ruminant species. If the additive l‐tryptophan is intended for use in ruminants, it should be protected from ruminal degradation. |
topic |
nutritional additive amino acids l‐tryptophan safety efficacy Escherichia coli KCCM 80135 |
url |
https://doi.org/10.2903/j.efsa.2019.5694 |
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