Association of high titers of anti-carbamylated protein antibodies with decreased bone mineral density in early arthritis patients.
Rheumatoid arthritis (RA) has a negative impact on bone that is partly mediated by anti-citrullinated proteins antibodies (ACPA). These antibodies are associated with erosions, and with juxta-articular and systemic bone loss. Other RA autoantibodies, the anti-carbamylated protein antibodies (anti-Ca...
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doaj-e9c4d652b6e3496db99150c53a4659a72020-11-24T21:14:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01138e020258310.1371/journal.pone.0202583Association of high titers of anti-carbamylated protein antibodies with decreased bone mineral density in early arthritis patients.Cristina RegueiroAna M OrtizMaria Dolores BovedaSantos CastañedaIsidoro Gonzalez-AlvaroAntonio GonzalezRheumatoid arthritis (RA) has a negative impact on bone that is partly mediated by anti-citrullinated proteins antibodies (ACPA). These antibodies are associated with erosions, and with juxta-articular and systemic bone loss. Other RA autoantibodies, the anti-carbamylated protein antibodies (anti-CarPA), are independently associated with erosions. However, we do not know if they are also associated with juxta-articular and systemic bone loss. Here, we have addressed this question with data from 548 early arthritis (EA) patients. Bone mineral density (BMD) was assessed by dual-energy x-ray absorptiometry at the lumbar spine (LS), total hip (TH) and metacarpophalangeal joints (MCP). The 25.9% anti-CarPA positive patients did not show significant differences in BMD Z-scores with the negative patients. Nevertheless, this result was due to the similarity between negative and low-positive (below the median of the positive) patients, whereas the high-positive patients showed significant decrease of BMD at LS (β = -0.39, p = 0.01) and TH (β = -0.30, p = 0.02); but not at the juxta-articular bone of MCP. Given the overlap between anti-CarPA and ACPA, we included the two autoantibodies in an analysis that showed significantly lower BMD Z-scores at LS and TH (p< 0.01) only in the ACPA positive/anti-CarPA high-positive subgroup. However, the similar coefficients of regression between the ACPA positive/anti-CarPA high-positive and the ACPA negative/anti-CarPA high-positive subgroups (β = -0.50 vs. -0.52 at LS, and β = -0.37 vs. -0.30 at TH) suggested an independent association. Overall, these results support a contribution of anti-CarPA to systemic bone loss in EA patients.http://europepmc.org/articles/PMC6097678?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Cristina Regueiro Ana M Ortiz Maria Dolores Boveda Santos Castañeda Isidoro Gonzalez-Alvaro Antonio Gonzalez |
spellingShingle |
Cristina Regueiro Ana M Ortiz Maria Dolores Boveda Santos Castañeda Isidoro Gonzalez-Alvaro Antonio Gonzalez Association of high titers of anti-carbamylated protein antibodies with decreased bone mineral density in early arthritis patients. PLoS ONE |
author_facet |
Cristina Regueiro Ana M Ortiz Maria Dolores Boveda Santos Castañeda Isidoro Gonzalez-Alvaro Antonio Gonzalez |
author_sort |
Cristina Regueiro |
title |
Association of high titers of anti-carbamylated protein antibodies with decreased bone mineral density in early arthritis patients. |
title_short |
Association of high titers of anti-carbamylated protein antibodies with decreased bone mineral density in early arthritis patients. |
title_full |
Association of high titers of anti-carbamylated protein antibodies with decreased bone mineral density in early arthritis patients. |
title_fullStr |
Association of high titers of anti-carbamylated protein antibodies with decreased bone mineral density in early arthritis patients. |
title_full_unstemmed |
Association of high titers of anti-carbamylated protein antibodies with decreased bone mineral density in early arthritis patients. |
title_sort |
association of high titers of anti-carbamylated protein antibodies with decreased bone mineral density in early arthritis patients. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2018-01-01 |
description |
Rheumatoid arthritis (RA) has a negative impact on bone that is partly mediated by anti-citrullinated proteins antibodies (ACPA). These antibodies are associated with erosions, and with juxta-articular and systemic bone loss. Other RA autoantibodies, the anti-carbamylated protein antibodies (anti-CarPA), are independently associated with erosions. However, we do not know if they are also associated with juxta-articular and systemic bone loss. Here, we have addressed this question with data from 548 early arthritis (EA) patients. Bone mineral density (BMD) was assessed by dual-energy x-ray absorptiometry at the lumbar spine (LS), total hip (TH) and metacarpophalangeal joints (MCP). The 25.9% anti-CarPA positive patients did not show significant differences in BMD Z-scores with the negative patients. Nevertheless, this result was due to the similarity between negative and low-positive (below the median of the positive) patients, whereas the high-positive patients showed significant decrease of BMD at LS (β = -0.39, p = 0.01) and TH (β = -0.30, p = 0.02); but not at the juxta-articular bone of MCP. Given the overlap between anti-CarPA and ACPA, we included the two autoantibodies in an analysis that showed significantly lower BMD Z-scores at LS and TH (p< 0.01) only in the ACPA positive/anti-CarPA high-positive subgroup. However, the similar coefficients of regression between the ACPA positive/anti-CarPA high-positive and the ACPA negative/anti-CarPA high-positive subgroups (β = -0.50 vs. -0.52 at LS, and β = -0.37 vs. -0.30 at TH) suggested an independent association. Overall, these results support a contribution of anti-CarPA to systemic bone loss in EA patients. |
url |
http://europepmc.org/articles/PMC6097678?pdf=render |
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