Zinc-mediated conformational preselection mechanism in the allosteric control of DNA binding to the zinc transcriptional regulator (ZitR)
Abstract The zinc transcriptional regulator (ZitR) functions as a metalloregulator that fine tunes transcriptional regulation through zinc-dependent DNA binding. However, the molecular mechanism of zinc-driven allosteric control of the DNA binding to ZitR remains elusive. Here, we performed enhanced...
Main Authors: | Xinheng He, Duan Ni, Hao Zhang, Xinyi Li, Jian Zhang, Qiang Fu, Yaqin Liu, Shaoyong Lu |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-08-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-70381-8 |
Similar Items
-
Allosteric Inhibition of Zinc Finger Proteins by DNA Binding Polyamides
by: Nguyen Hackley, Doan Hanh
Published: (2002) -
Conformational transition pathway in the activation process of allosteric glucokinase.
by: Min Huang, et al.
Published: (2013-01-01) -
Investigation of the Role of Genes Encoding Zinc Exporters zntA, zitB, and fieF during Salmonella Typhimurium Infection
by: Kaisong Huang, et al.
Published: (2018-01-01) -
Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design
by: Shaoyong Lu, et al.
Published: (2021-08-01) -
Mechanism of allosteric activation of SIRT6 revealed by the action of rationally designed activators
by: Shaoyong Lu, et al.
Published: (2021-05-01)