Exercise training complementary to specialised early intervention in patients with first-episode psychosis: a feasibility randomised trial
Abstract Background The aim of this study was to examine feasibility of trial processes and group-based, structured exercise training in patients with first-episode psychosis. Methods Twenty-five patients with first-episode psychosis took part in a two-arm randomised feasibility trial. They were ind...
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doaj-e9cac4bd628548d9bd327c43e7a59c9a2021-08-22T11:15:07ZengBMCPilot and Feasibility Studies2055-57842021-08-017111110.1186/s40814-021-00900-5Exercise training complementary to specialised early intervention in patients with first-episode psychosis: a feasibility randomised trialJulie Midtgaard0Helle Schnor1Eik D. Bjerre2Tobias Jespersen3Nina Jelsøe4Nanna Frølund5Søren Seier6Jacob W. Rønbøg7Nikolai B. Nordsborg8Bjørn H. Ebdrup9Mental Health Centre Glostrup, University of CopenhagenMental Health Centre Glostrup, University of CopenhagenThe University Hospitals Centre for Health Research, Copenhagen University Hospital – RigshospitaletMental Health Centre Glostrup, University of CopenhagenDepartment of Nutrition, Exercise and Sports, University of CopenhagenDepartment of Nutrition, Exercise and Sports, University of CopenhagenDepartment of Nutrition, Exercise and Sports, University of CopenhagenDepartment of Nutrition, Exercise and Sports, University of CopenhagenDepartment of Nutrition, Exercise and Sports, University of CopenhagenMental Health Centre Glostrup, University of CopenhagenAbstract Background The aim of this study was to examine feasibility of trial processes and group-based, structured exercise training in patients with first-episode psychosis. Methods Twenty-five patients with first-episode psychosis took part in a two-arm randomised feasibility trial. They were individually randomised (1:1) via a computer-generated randomisation sequence and allocated to either an exercise intervention group (INT) or a control group (CON). Patients allocated to INT completed a physical exercise training programme at moderate-to-vigorous intensity, 1 h three times weekly for 8 weeks. CON patients were encouraged to continue their usual level of activity and were offered the training programme after 8 weeks. Primary outcomes included screening rate, recruitment rate, retention rate, attendance and adverse events. Secondary outcomes included heart rate response during training, cardiovascular health (VO2max, resting heart rate, blood pressure), body composition (muscle mass, fat percentage), muscle strength (sit-to-stand, grip strength, jump height) and balance. Results Recruitment lasted 6 weeks and 86 out of 324 patients (27%) were screened, 71 of whom (83%) were deemed eligible. Twenty-five (35%) accepted inclusion (mean age 25.5; mean body mass index 25.1) and were subsequently randomised (INT = 13, CON = 12). Retention of patients was 76% and 52% at the 8-week and 16-week follow-up, respectively. Attendance was 43% (min. 9%, max. 96%). No significant changes were observed between groups in secondary physiological outcome measures. Conclusions Feasibility was challenged by limited recruitment and retention rates, suggesting that modifications are required if a large-scale randomised controlled trial is to be conducted. Recommendations for modifications are presented and discussed. Trial registration Clinicaltrials.gov, NCT03409393 . Retrospectively registered.https://doi.org/10.1186/s40814-021-00900-5Exercise trainingFeasibilityFirst-episode psychosisRandomised trial |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Julie Midtgaard Helle Schnor Eik D. Bjerre Tobias Jespersen Nina Jelsøe Nanna Frølund Søren Seier Jacob W. Rønbøg Nikolai B. Nordsborg Bjørn H. Ebdrup |
spellingShingle |
Julie Midtgaard Helle Schnor Eik D. Bjerre Tobias Jespersen Nina Jelsøe Nanna Frølund Søren Seier Jacob W. Rønbøg Nikolai B. Nordsborg Bjørn H. Ebdrup Exercise training complementary to specialised early intervention in patients with first-episode psychosis: a feasibility randomised trial Pilot and Feasibility Studies Exercise training Feasibility First-episode psychosis Randomised trial |
author_facet |
Julie Midtgaard Helle Schnor Eik D. Bjerre Tobias Jespersen Nina Jelsøe Nanna Frølund Søren Seier Jacob W. Rønbøg Nikolai B. Nordsborg Bjørn H. Ebdrup |
author_sort |
Julie Midtgaard |
title |
Exercise training complementary to specialised early intervention in patients with first-episode psychosis: a feasibility randomised trial |
title_short |
Exercise training complementary to specialised early intervention in patients with first-episode psychosis: a feasibility randomised trial |
title_full |
Exercise training complementary to specialised early intervention in patients with first-episode psychosis: a feasibility randomised trial |
title_fullStr |
Exercise training complementary to specialised early intervention in patients with first-episode psychosis: a feasibility randomised trial |
title_full_unstemmed |
Exercise training complementary to specialised early intervention in patients with first-episode psychosis: a feasibility randomised trial |
title_sort |
exercise training complementary to specialised early intervention in patients with first-episode psychosis: a feasibility randomised trial |
publisher |
BMC |
series |
Pilot and Feasibility Studies |
issn |
2055-5784 |
publishDate |
2021-08-01 |
description |
Abstract Background The aim of this study was to examine feasibility of trial processes and group-based, structured exercise training in patients with first-episode psychosis. Methods Twenty-five patients with first-episode psychosis took part in a two-arm randomised feasibility trial. They were individually randomised (1:1) via a computer-generated randomisation sequence and allocated to either an exercise intervention group (INT) or a control group (CON). Patients allocated to INT completed a physical exercise training programme at moderate-to-vigorous intensity, 1 h three times weekly for 8 weeks. CON patients were encouraged to continue their usual level of activity and were offered the training programme after 8 weeks. Primary outcomes included screening rate, recruitment rate, retention rate, attendance and adverse events. Secondary outcomes included heart rate response during training, cardiovascular health (VO2max, resting heart rate, blood pressure), body composition (muscle mass, fat percentage), muscle strength (sit-to-stand, grip strength, jump height) and balance. Results Recruitment lasted 6 weeks and 86 out of 324 patients (27%) were screened, 71 of whom (83%) were deemed eligible. Twenty-five (35%) accepted inclusion (mean age 25.5; mean body mass index 25.1) and were subsequently randomised (INT = 13, CON = 12). Retention of patients was 76% and 52% at the 8-week and 16-week follow-up, respectively. Attendance was 43% (min. 9%, max. 96%). No significant changes were observed between groups in secondary physiological outcome measures. Conclusions Feasibility was challenged by limited recruitment and retention rates, suggesting that modifications are required if a large-scale randomised controlled trial is to be conducted. Recommendations for modifications are presented and discussed. Trial registration Clinicaltrials.gov, NCT03409393 . Retrospectively registered. |
topic |
Exercise training Feasibility First-episode psychosis Randomised trial |
url |
https://doi.org/10.1186/s40814-021-00900-5 |
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