Downregulation of FGF Signaling by Spry4 Overexpression Leads to Shape Impairment, Enamel Irregularities, and Delayed Signaling Center Formation in the Mouse Molar

Downregulation of FGF Signaling by Spry4 Overexpression Leads to Shape Impairment, Enamel Irregularities, and Delayed Signaling Center Formation in the Mouse Molar

ABSTRACT FGF signaling plays a critical role in tooth development, and mutations in modulators of this pathway produce a number of striking phenotypes. However, many aspects of the role of the FGF pathway in regulating the morphological features and the mineral quality of the dentition remain unknow...

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Bibliographic Details
Main Authors: Pauline Marangoni, Cyril Charles, Youngwook Ahn, Kerstin Seidel, Andrew Jheon, Bernhard Ganss, Robb Krumlauf, Laurent Viriot, Ophir D Klein
Format: Article
Language:English
Published: Wiley 2019-08-01
Series:JBMR Plus
Subjects:
FGF SIGNALING
ENAMEL MINERALIZATION DEFECT
TOOTH DEVELOPMENT
SPRY4
Online Access:https://doi.org/10.1002/jbm4.10205

Internet

https://doi.org/10.1002/jbm4.10205

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