Downregulation of FGF Signaling by Spry4 Overexpression Leads to Shape Impairment, Enamel Irregularities, and Delayed Signaling Center Formation in the Mouse Molar
ABSTRACT FGF signaling plays a critical role in tooth development, and mutations in modulators of this pathway produce a number of striking phenotypes. However, many aspects of the role of the FGF pathway in regulating the morphological features and the mineral quality of the dentition remain unknow...
Main Authors: | Pauline Marangoni, Cyril Charles, Youngwook Ahn, Kerstin Seidel, Andrew Jheon, Bernhard Ganss, Robb Krumlauf, Laurent Viriot, Ophir D Klein |
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Format: | Article |
Language: | English |
Published: |
Wiley
2019-08-01
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Series: | JBMR Plus |
Subjects: | |
Online Access: | https://doi.org/10.1002/jbm4.10205 |
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