17-AAG kills intracellular Leishmania amazonensis while reducing inflammatory responses in infected macrophages.
BACKGROUND: Leishmaniasis is a neglected endemic disease with a broad spectrum of clinical manifestations. Pentavalent antimonials have been the treatment of choice for the past 70 years and, due to the emergence of resistant cases, the efficacy of these drugs has come under scrutiny. Second-line dr...
Main Authors: | Antonio Luis de Oliveira Almeida Petersen, Carlos Eduardo Sampaio Guedes, Carolina Leite Versoza, José Geraldo Bomfim Lima, Luiz Antônio Rodrigues de Freitas, Valéria Matos Borges, Patrícia Sampaio Tavares Veras |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2012-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC3496716?pdf=render |
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