A TFEB nuclear export signal integrates amino acid supply and glucose availability

On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that requires dual phosphorylation at the S142 ERK/mTORC1 and S138 GSK3β sites, and further show glucose limitation drives nuclear accumulation of TFEB and inhibit...

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Main Authors:	Linxin Li, Hans J. Friedrichsen, Sarah Andrews, Sarah Picaud, Laurent Volpon, Kaochin Ngeow, Georgina Berridge, Roman Fischer, Katherine L. B. Borden, Panagis Filippakopoulos, Colin R. Goding
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-04849-7

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spelling	doaj-e9d8aa256d4f4d8c979b588562b4a5e72021-05-11T09:31:27ZengNature Publishing GroupNature Communications2041-17232018-07-019111510.1038/s41467-018-04849-7A TFEB nuclear export signal integrates amino acid supply and glucose availabilityLinxin Li0Hans J. Friedrichsen1Sarah Andrews2Sarah Picaud3Laurent Volpon4Kaochin Ngeow5Georgina Berridge6Roman Fischer7Katherine L. B. Borden8Panagis Filippakopoulos9Colin R. Goding10Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of OxfordLudwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of OxfordLudwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of OxfordStructural Genomics Consortium, Nuffield Department of Clinical Medicine, University of OxfordInstitute of Research in Immunology and Cancer (IRIC), Department of Pathology and Cell Biology, Université de Montréal, Pavillon Marcel-Coutou, Chemin de la PolytechniqueLudwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of OxfordLudwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of OxfordDiscovery Proteomics Facility, Target Discovery Institute, Nuffield Department of Clinical Medicine, University of OxfordInstitute of Research in Immunology and Cancer (IRIC), Department of Pathology and Cell Biology, Université de Montréal, Pavillon Marcel-Coutou, Chemin de la PolytechniqueLudwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of OxfordLudwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of OxfordOn amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that requires dual phosphorylation at the S142 ERK/mTORC1 and S138 GSK3β sites, and further show glucose limitation drives nuclear accumulation of TFEB and inhibits GSK3β via an mTORC2-AKT dependent mechanism.https://doi.org/10.1038/s41467-018-04849-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Linxin Li Hans J. Friedrichsen Sarah Andrews Sarah Picaud Laurent Volpon Kaochin Ngeow Georgina Berridge Roman Fischer Katherine L. B. Borden Panagis Filippakopoulos Colin R. Goding
spellingShingle	Linxin Li Hans J. Friedrichsen Sarah Andrews Sarah Picaud Laurent Volpon Kaochin Ngeow Georgina Berridge Roman Fischer Katherine L. B. Borden Panagis Filippakopoulos Colin R. Goding A TFEB nuclear export signal integrates amino acid supply and glucose availability Nature Communications
author_facet	Linxin Li Hans J. Friedrichsen Sarah Andrews Sarah Picaud Laurent Volpon Kaochin Ngeow Georgina Berridge Roman Fischer Katherine L. B. Borden Panagis Filippakopoulos Colin R. Goding
author_sort	Linxin Li
title	A TFEB nuclear export signal integrates amino acid supply and glucose availability
title_short	A TFEB nuclear export signal integrates amino acid supply and glucose availability
title_full	A TFEB nuclear export signal integrates amino acid supply and glucose availability
title_fullStr	A TFEB nuclear export signal integrates amino acid supply and glucose availability
title_full_unstemmed	A TFEB nuclear export signal integrates amino acid supply and glucose availability
title_sort	tfeb nuclear export signal integrates amino acid supply and glucose availability
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-07-01
description	On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that requires dual phosphorylation at the S142 ERK/mTORC1 and S138 GSK3β sites, and further show glucose limitation drives nuclear accumulation of TFEB and inhibits GSK3β via an mTORC2-AKT dependent mechanism.
url	https://doi.org/10.1038/s41467-018-04849-7
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A TFEB nuclear export signal integrates amino acid supply and glucose availability

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