Long non-coding RNAs: Functional regulatory players in breast cancer
Historically, the long-held protein-centered bias has denoted 98% of the human genome as ‘Junk’ DNA. However, the current work has shifted the perception of such 'junk' transcriptional products to functional regulatory molecules. The recent surveillance of the human transcriptome has highl...
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KeAi Communications Co., Ltd.
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doaj-e9dfce8d5e1b47559bb0913264166dfd2021-02-02T06:39:55ZengKeAi Communications Co., Ltd.Non-coding RNA Research2468-05402019-03-01413644Long non-coding RNAs: Functional regulatory players in breast cancerRana Ahmed Youness0Mohamed Zakaria Gad1Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, New Cairo City, Main Entrance Al Tagamoa Al Khames, 11835, Cairo, Egypt; Corresponding author.Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, New Cairo City, Main Entrance Al Tagamoa Al Khames, 11835, Cairo, EgyptHistorically, the long-held protein-centered bias has denoted 98% of the human genome as ‘Junk’ DNA. However, the current work has shifted the perception of such 'junk' transcriptional products to functional regulatory molecules. The recent surveillance of the human transcriptome has highlighted the pivotal role of such non-coding RNA (ncRNA) molecules in diverse physiological and pathological conditions. Long non-coding RNA (lncRNA) is a recent class of ncRNA molecules that is still in its infancy stage. The main focus of this review is to unravel the importance of lncRNAs in the most prevalent malignancy among females which is Breast Cancer (BC). A specific focus on lncRNAs as prognostic markers among BC patients showing molecular subtype heterogeneity was also tackled in this review. Finally, the functional and the mechanistic roles of such booming ncRNA molecules in shaping the fate of the BC progression have been highlighted.http://www.sciencedirect.com/science/article/pii/S2468054018300842 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rana Ahmed Youness Mohamed Zakaria Gad |
spellingShingle |
Rana Ahmed Youness Mohamed Zakaria Gad Long non-coding RNAs: Functional regulatory players in breast cancer Non-coding RNA Research |
author_facet |
Rana Ahmed Youness Mohamed Zakaria Gad |
author_sort |
Rana Ahmed Youness |
title |
Long non-coding RNAs: Functional regulatory players in breast cancer |
title_short |
Long non-coding RNAs: Functional regulatory players in breast cancer |
title_full |
Long non-coding RNAs: Functional regulatory players in breast cancer |
title_fullStr |
Long non-coding RNAs: Functional regulatory players in breast cancer |
title_full_unstemmed |
Long non-coding RNAs: Functional regulatory players in breast cancer |
title_sort |
long non-coding rnas: functional regulatory players in breast cancer |
publisher |
KeAi Communications Co., Ltd. |
series |
Non-coding RNA Research |
issn |
2468-0540 |
publishDate |
2019-03-01 |
description |
Historically, the long-held protein-centered bias has denoted 98% of the human genome as ‘Junk’ DNA. However, the current work has shifted the perception of such 'junk' transcriptional products to functional regulatory molecules. The recent surveillance of the human transcriptome has highlighted the pivotal role of such non-coding RNA (ncRNA) molecules in diverse physiological and pathological conditions. Long non-coding RNA (lncRNA) is a recent class of ncRNA molecules that is still in its infancy stage. The main focus of this review is to unravel the importance of lncRNAs in the most prevalent malignancy among females which is Breast Cancer (BC). A specific focus on lncRNAs as prognostic markers among BC patients showing molecular subtype heterogeneity was also tackled in this review. Finally, the functional and the mechanistic roles of such booming ncRNA molecules in shaping the fate of the BC progression have been highlighted. |
url |
http://www.sciencedirect.com/science/article/pii/S2468054018300842 |
work_keys_str_mv |
AT ranaahmedyouness longnoncodingrnasfunctionalregulatoryplayersinbreastcancer AT mohamedzakariagad longnoncodingrnasfunctionalregulatoryplayersinbreastcancer |
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