Dysregulation of the autophagic-lysosomal pathway in Gaucher and Parkinson's disease

The finding that mutations in the Gaucher's Disease (GD) gene GBA1 are a strong risk factor for Parkinson's Disease (PD) has allowed for unique insights into pathophysiology centered on disruption of the autophagic-lysosomal pathway. Protein aggregations in the form of Lewy bodies and the...

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Bibliographic Details
Main Authors: Caleb Pitcairn, Willayat Yousuf Wani, Joseph R. Mazzulli
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118300743

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