Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study
Abstract Background Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stiffness, and examined whether there were effect modifiers, in hypertensiv...
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doaj-e9fd78963d554ccdbf016952518149982020-11-25T03:13:31ZengBMCCardiovascular Diabetology1475-28402020-09-011911910.1186/s12933-020-01124-2Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry StudyMinghui Li0Aihua Zhan1Xiao Huang2Lihua Hu3Wei Zhou4Tao Wang5Lingjuan Zhu6Huihui Bao7Xiaoshu Cheng8Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityZheyuan township hospitalDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityDepartment of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang UniversityAbstract Background Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stiffness, and examined whether there were effect modifiers, in hypertensive patients. Methods This study included 4718 hypertensive adults, a subset of the China H-type Hypertension Registry Study. The TyG index was calculated as ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was determined by measuring brachial-ankle pulse wave velocity (baPWV). Results The overall mean TyG index was 8.84. Multivariate linear regression analyses showed that TyG index was independently and positively associated with baPWV (β, 1.02; 95% confidence interval [CI] 0.83, 1.20). Consistently, Multiple logistic analyses showed a positive association between TyG index risk of elevated baPWV (> 75th percentile) (odds ratio [OR], 2.12; 95% CI 1.80, 2.50). Analyses using restricted cubic spline confirmed that the associations of TyG index with baPWV and elevated baPWV were linear. Subgroup analyses showed that stronger associations between TyG index and baPWV were detected in men (all P for interaction < 0.05). Conclusion TyG index was independently and positively associated with baPWV and elevated baPWV among hypertensive patients, especially in men. The data suggest that TyG index may serve as a simple and effective tool for arterial stiffness risk assessment in daily clinical practice.http://link.springer.com/article/10.1186/s12933-020-01124-2Triglyceride glucose indexBrachial-ankle pulse wave velocityArterial stiffnessHypertension |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Minghui Li Aihua Zhan Xiao Huang Lihua Hu Wei Zhou Tao Wang Lingjuan Zhu Huihui Bao Xiaoshu Cheng |
spellingShingle |
Minghui Li Aihua Zhan Xiao Huang Lihua Hu Wei Zhou Tao Wang Lingjuan Zhu Huihui Bao Xiaoshu Cheng Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study Cardiovascular Diabetology Triglyceride glucose index Brachial-ankle pulse wave velocity Arterial stiffness Hypertension |
author_facet |
Minghui Li Aihua Zhan Xiao Huang Lihua Hu Wei Zhou Tao Wang Lingjuan Zhu Huihui Bao Xiaoshu Cheng |
author_sort |
Minghui Li |
title |
Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study |
title_short |
Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study |
title_full |
Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study |
title_fullStr |
Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study |
title_full_unstemmed |
Positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the China H-type Hypertension Registry Study |
title_sort |
positive association between triglyceride glucose index and arterial stiffness in hypertensive patients: the china h-type hypertension registry study |
publisher |
BMC |
series |
Cardiovascular Diabetology |
issn |
1475-2840 |
publishDate |
2020-09-01 |
description |
Abstract Background Data are limited on whether TyG index is an independent predictor of arterial stiffness in hypertensive patients. The purpose of this study was to assess the association between the TyG index and arterial stiffness, and examined whether there were effect modifiers, in hypertensive patients. Methods This study included 4718 hypertensive adults, a subset of the China H-type Hypertension Registry Study. The TyG index was calculated as ln[fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. Arterial stiffness was determined by measuring brachial-ankle pulse wave velocity (baPWV). Results The overall mean TyG index was 8.84. Multivariate linear regression analyses showed that TyG index was independently and positively associated with baPWV (β, 1.02; 95% confidence interval [CI] 0.83, 1.20). Consistently, Multiple logistic analyses showed a positive association between TyG index risk of elevated baPWV (> 75th percentile) (odds ratio [OR], 2.12; 95% CI 1.80, 2.50). Analyses using restricted cubic spline confirmed that the associations of TyG index with baPWV and elevated baPWV were linear. Subgroup analyses showed that stronger associations between TyG index and baPWV were detected in men (all P for interaction < 0.05). Conclusion TyG index was independently and positively associated with baPWV and elevated baPWV among hypertensive patients, especially in men. The data suggest that TyG index may serve as a simple and effective tool for arterial stiffness risk assessment in daily clinical practice. |
topic |
Triglyceride glucose index Brachial-ankle pulse wave velocity Arterial stiffness Hypertension |
url |
http://link.springer.com/article/10.1186/s12933-020-01124-2 |
work_keys_str_mv |
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